We started out making dyes for single-particle tracking in cultured cells. But now we have dyes that enable pulse-chase labeling in vivo. Read the preprint here, a project driven by the indefatigable Boaz Mohar (@[email protected]) with other colleagues at HHMI | Janelia biorxiv.org/content/10.110…

Our new review is out in Nature Reviews Microbiology: Molecular Mechanisms of Antibiotic Resistance Revisited. Dr Lizzy Darby Ilyas Alav Mark Webber Eleftheria Trampari Maria Solsona & Pauline IMIBirmingham Quadram Institute #WAAW 😃 nature.com/articles/s4157…

Plan early for next summer! Great opportunity for undergrad students who'd like to do research over the summer.

What happens when bacterial genomes are put in a eukaryotic context? A lot! Both expected and surprising! We characterized chromatin assembly, activity, folding and compartmentalization of Mb long bacterial genomes put in a yeast nucleus. A v2! #3Dgenome biorxiv.org/content/10.110…

It was impressive reviewing the papers from our field to show how far understanding has come for the quantitative aspects of bacterial cell surfaces and the processes by which they are made rdcu.be/c6iIS Centre to Impact AMR MACSYS-CoE Monash Biomedicine Discovery Institute

A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery doi.org/10.1016/j.cell…

Thermal agitation is slow and ineffective when it comes to self-assembling soft materials. Can active baths do better? Today in Nature Physics, we show that a (chiral) active bath can rapidly⚡️build extraordinary structures unreachable to thermal physics👽 nature.com/articles/s4156…

RNA polymerase generates equal amount of positive and negative supercoils upon DNA unwinding, and does so in an RNA independent manner. Intriguing dtudy from CD lab. Very interesting! cees dekker biorxiv.org/content/10.110…

Thank you Katsu Murakami for inviting me! I had a great day talking with your faculty and students!

Our new findings on how the ribosome couples with the RNA polymerase are summarized in a movie highlighting the dynamics of the process🎞️🎥 Thanks to Clemens Bretscher for the great animations! - behance.net/cbretscher EMBL paper in bioRxiv biorxiv.org/content/10.110…

A dream of our lab has been to image the full central dogma from a single endogenous gene, all live and with single molecule resolution. After many years we are happy to unveil a beautiful cell line that makes it possible. Check out our preprint (biorxiv.org/content/10.110…)! (1/n)

We used a multi-resolution simulation strategy to package the entire 39,732 base pair genome into a 65-nm diameter capsid. By gradually increasing the resolution of the model, we arrive at a fully atomistic, explicit solvent representation of the HK97 virion

Coupled or not coupled? In this preprint, we explored conditions that affect coupling (or uncoupling) between transcription, translation, and mRNA degradation in bacteria. biorxiv.org/content/10.110…

For building a synthetic cell, we will need to access the information carried in large DNA molecules. We used active learning to adapt in vitro gene expression to E. coli's chromosomes with a surprising efficiency. Synthetic Cell initiative Now out in ACS_Omega 🥳 👉doi.org/10.1021/acsome…

Yay! Kim lab finished strong in the Illinois 5k race Illinois Marathon

So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulations to the team of Ari Sarfatis, Yuanyou Wang, and Nana Twumasi-Ankrah! Check out the following thread or our bioRxiv (biorxiv.org/content/10.110…) 1/12

Online Now: Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle dlvr.it/T96Bc8

Check out our latest findings on the epitranscriptome of Escherichia coli biorxiv.org/cgi/content/sh… , spearheaded by #Sebastian Riquelme-Barrios and in excellent collaboration with Pascal Giehr 🕊🇺🇦 and Kaiser Lab; funded by @sfb1309.

A 'CRISPR' way to see individual endogenous RNA molecules in live cells. Check our latest preprint: biorxiv.org/content/10.110…