Kudos to University Hospital Ayr (Scotland🏴󠁧󠁢󠁳󠁣󠁴󠁿🇬🇧) for randomizing their 1st patient into The STARRT-AKI Trial! Sean Bagshaw Ron Wald CCCTG Danny McAuley UKCCRG #aki #rrt #starrtaki

Congratulations to the Team from Juravinski Hospital (Hamilton 🇨🇦) for enrolling their 💯th patient into The STARRT-AKI Trial! Magnificent contribution & inspiring dedication! Sean Bagshaw Ron Wald CCCTG Bram Rochwerg Tim Karachi Happy 🇨🇦 Day to all our amazing Canadian sites!

Happy weekend to all our investigators and coordinators, all our participating intensivists, nurses and patients and any interested followers! The STARRT-AKI Trial is 2958/3000 complete! Magic number is 42! Help us in this final push! Sean Bagshaw Ron Wald CCCTG ANZICS UKCCRG

We are proud to announce The STARRT-AKI Trial has completed target recruitment of 3000 patients! Huge kudos to our investigators, research teams, and patients/families in 15 nations and 168 sites! Sean Bagshaw Ron Wald CCCTG ANZICS UKCCRG Irish Critical Care Clinical Trials Network 🇨🇦🇦🇺🇦🇹🇧🇷🇧🇪🇨🇳🇫🇮🇫🇷🇩🇪🇮🇪🇮🇹🇳🇿🇨🇭🇬🇧🇺🇸

Thanks again to all our investigative teams for their commitment and global collaboration to successfully complete the The STARRT-AKI Trial trial - results of the main trial will be available soon Sean Bagshaw Ron Wald CCCTG ANZICS Clinical Trials Group Irish Critical Care Clinical Trials Network UKCCRG

The STARRT-AKI Trial results very soon! Stay tuned. In the meantime over the few days we will share the "STARRT-AKI Index" - a summary of fun facts related to the trial Sean Bagshaw Ron Wald CCCTG ANZICS Clinical Trials Group Irish Critical Care Clinical Trials Network UKCCRG

The STARRT-AKI Trial Index fact for today: 1/10 - No. of investigators and research personnel (across 15 countries & 168 activated sites): 840 Sean Bagshaw Ron Wald CCCTG ANZICS Clinical Trials Group Irish Critical Care Clinical Trials Network UKCCRG 🇨🇦🇦🇺🇦🇹🇧🇷🇧🇪🇨🇳🇫🇮🇫🇷🇩🇪🇮🇪🇮🇹🇳🇿🇨🇭🇬🇧🇺🇸🌎

2/10 - No. of database entries for all patients enrolled in The STARRT-AKI Trial: 886,149 Sean Bagshaw Ron Wald CCCTG ANZICS Clinical Trials Group Irish Critical Care Clinical Trials Network UKCCRG 🇨🇦🇦🇺🇦🇹🇧🇪🇧🇷🇨🇳🇫🇮🇫🇷🇩🇪🇮🇪🇮🇹🇳🇿🇨🇭🇬🇧🇺🇸🌍🌏🌎

3/10 - N. of trial-related teleconferences and webinars for The STARRT-AKI Trial: 414 Sean Bagshaw Ron Wald CCCTG ANZICS Clinical Trials Group Irish Critical Care Clinical Trials Network UKCCRG 🇨🇦🇦🇺🇦🇹🇩🇪🇧🇷🇨🇳🇫🇮🇫🇷🇧🇪🇮🇹🇮🇪🇳🇿🇨🇭🇺🇸🇬🇧🌍🌏🌎

4/10 - No. of trial-related emails (estimated): >60,000 Sean Bagshaw Ron Wald CCCTG ANZICS Clinical Trials Group Irish Critical Care Clinical Trials Network UKCCRG 🇨🇦🇦🇺🇦🇹🇧🇪🇧🇷🇨🇳🇫🇮🇫🇷🇩🇪🇮🇹🇮🇪🇳🇿🇨🇭🇺🇸🇬🇧🌍🌏🌎

5/10 - No. of completed data queries during database cleaning: 16,825 Ron Wald Sean Bagshaw CCCTG ANZICS Clinical Trials Group Irish Critical Care Clinical Trials Network UKCCRG 🇨🇦🇦🇺🇦🇹🇧🇪🇧🇷🇨🇳🇫🇮🇫🇷🇩🇪🇮🇪🇮🇹🇳🇿🇨🇭🇬🇧🇺🇸 🌎🌏🌍

6/10 - No. of "site initiation visits" performed: 116 Sean Bagshaw Ron Wald CCCTG ANZICS Clinical Trials Group Irish Critical Care Clinical Trials Network UKCCRG 🇨🇦🇦🇺🇦🇹🇧🇪🇧🇷🇨🇳🇫🇮🇫🇷🇩🇪🇮🇪🇮🇹🇳🇿🇨🇭🇺🇸🇬🇧🌎🌏🌍

7/10 - No. of research grants received to support the trial: 10 Ron Wald Sean Bagshaw CCCTG Irish Critical Care Clinical Trials Network UKCCRG 🇨🇦🇦🇺🇦🇹🇧🇪🇧🇷🇨🇳🇫🇮🇫🇷🇩🇪🇮🇪🇮🇹🇳🇿🇨🇭🇺🇸🇬🇧🌎🌏🌍

8/10 - No. of languages used for trial-related documents and communication: 5 Sean Bagshaw Ron Wald CCCTG ANZICS Clinical Trials Group Irish Critical Care Clinical Trials Network UKCCRG 🇨🇦🇦🇺🇦🇹🇧🇪🇧🇷🇨🇳🇫🇮🇫🇷🇩🇪🇮🇪🇮🇹🇳🇿🇨🇭🇺🇸🇬🇧🌎🌏🌍

9/10 - No. of days from the first to the last patient randomized into the trial: 1437 (3 years, 11 months, 6 days) Sean Bagshaw Ron Wald CCCTG ANZICS Clinical Trials Group Irish Critical Care Clinical Trials Network UKCCRG 🇨🇦🇦🇺🇦🇹🇧🇪🇧🇷🇨🇳🇫🇮🇫🇷🇩🇪🇮🇪🇮🇹🇳🇿🇨🇭🇺🇸🇬🇧🌎🌏🌍

10/10 - No. of days from the first patient randomized to trial publication in NEJM: 1738 nejm.org/doi/full/10.10… Sean Bagshaw Ron Wald UAlberta Crit Care SMH Critical Care CCCTG ANZICS Clinical Trials Group Irish Critical Care Clinical Trials Network UKCCRG 🇨🇦🇦🇺🇦🇹🇧🇪🇧🇷🇨🇳🇫🇮🇫🇷🇩🇪🇮🇪🇮🇹🇳🇿🇨🇭🇺🇸🇬🇧🌎🌏🌍

Embedding equipoise into eligibility criteria of RCTs can be challenging. The STARRT-AKI Trial has now described and shared insights into this process bit.ly/3eJFMrZ Ron Wald CCCTG ANZICS Clinical Trials Group

New The STARRT-AKI Trial publication! Is there heterogeneity in treatment effect of RRT initiation strategies on outcomes by baseline risk of receiving RRT? Ron Wald Annals of the ATS CCCTG UAlberta Crit Care atsjournals.org/doi/10.1513/An…

New publication from The STARRT-AKI Trial - reanalysis of the main trial outcomes using a Bayesian approach Fernando Zampieri Ron Wald Francois Lamontagne Bram Rochwerg CCCTG UAlberta Crit Care ccforum.biomedcentral.com/articles/10.11… Critical Care

New The STARRT-AKI Trial publication! What is the impact of RRT initiation strategies among patients with CKD? Sean Bagshaw Ron Wald Rinaldo Bellomo Martin Gallagher Orla Smith See new secondary analysis at: link.springer.com/article/10.100… Intensive Care Medicine