#v2f Dr. Sheridan Littleton

ft. Dr. Sheridan Littleton, Khanh B. Trang, Christina Volpe, Kieona Cook, Nicole DeBruyne, Jean Ann Maguire, Mary Ann Weidekamp, Keith Boehm, Alessandra Chesi, James Pippin, Stewart Anderson, Andrew Wells, Matt Pahl & Struan Grant CHOP Research Penn Genetics tinyurl.com/hcbphwmv

Bye for now, Oulu, thank you for a wonderful time… Food for thought (science, health, population studies), collaborative spirit, and friendship 🇫🇮 Aminata Cissé Janine Felix Nicholas Timpson Bhargav Naveen, Sylvain Sebert Struan Grant Marjo-Riitta Jarvelin Elina Keikkala

Delighted to have contributed, along with my local colleagues Jonathan Bradfield, Diana Cousminer, @appliedgenomic and Babette Zemel. CHOP Research Penn Genetics

I’m thrilled to share that our work from the VA Research is finally out in Science Magazine ! We dive deep into the genetic architecture of 2,068 traits using data from the VA Million Veteran Program, comprising 635,969 Veteran. science.org/doi/10.1126/sc…

Congratulations to Benjamin Voight and co-mentee Mitch Conery for co-leading this key study just published in Science Magazine. Penn Genetics CHOP Research

Successfully defended my doctoral research! Thank you Todd Everson for your mentorship and support! Also special thank you to my committee members, co-authors, cohort, Emory Genetics and Molecular Biology, Emory University, my family and friends! #YourFavoriteScientist #PhinisheD

Exactly 6 years to the day since I started grad school, I am excited to share our preprint of my thesis work “Variant-to-function mapping of late-onset Alzheimer’s disease GWAS signals in human microglial models implicates RTFDC1 at the CASS4 locus” biorxiv.org/content/10.110…

Congratulations Eileen! Penn Medicine Penn Genetics

I can’t believe it’s really happening- I’m defending in a month! My defense is September 23rd at 11am in Smilow Rubinstein auditorium. I hope to see you there, and if you aren’t at Penn, I’m happy to provide you with the Zoom link if you’d like to attend virtually!

Our latest preprint, first author Khanh B. Trang: "Shared and unique 3D genomic features of substance use disorders across multiple cell types” CHOP Research Penn Genetics medrxiv.org/content/10.110…

A pleasure editing a book entitled "Genetics of Sleep and Sleep Disorders" with Phil Gehrman (SNAP lab) and Alex Keene. Many thanks to all who contributed! Penn Genetics CHOP Research link.springer.com/book/10.1007/9…

Led by Pol Solé-Navais & Bo Jacobsson in Nature Communications: "Genome-wide analyses of neonatal jaundice reveal a marked departure from adult bilirubin metabolism". Contributed with Applied Genomics & Jonathan Bradfield locally. CHOP Research Penn Genetics nature.com/articles/s4146…

PREPRINT: Led by Khanh B. Trang & Andrew Wells: "3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility”. CHOP Research Penn Genetics medrxiv.org/content/10.110…

Co-led with Matt Pahl - just out in Diabetologia, promoter-focused Capture-C datasets in relevant metabolic cellular models. Can serve as #v2f resource for implicating effector genes for type 2 diabetes and related traits. CHOP Research Penn Genetics doi.org/10.1007/s00125…

Consistent with our experience in the lab and 5 Prime Sciences, eQTLs are not consistently helpful to map causal genes at GWAS loci: cell.com/action/showPdf…

Excited to see the revised version of our paper now published at Cell Genomics led by Yevgeniy Serebrenik cell.com/cell-genomics/…

As my defense creeps ever closer(!!), I’m so happy to share that immediately after my defense, I’ll be moving to Boston to start a postdoc with Melina Claussnitzer and JT Neal at The Broad Institute! I cannot wait to get started and have a new adventure up North 😊

Wachowski et al report 100s of putative regulatory elements & effector genes at T2D GWAS loci using 3D genomics in relevant cell lines. SMCO4 KD in EndoC-BH1 increased insulin secretion. #GWAS #Genomics #InsulinSecretion Struan Grant Matt Pahl tinyurl.com/y4rczm8y 🔓