I’m not sure if anyone from CIHR-ICRH | L'ISCR des IRSC has noticed, but 3/14 landmark, practice-changing studies at this incredible international conference have been led/co-led by 🇨🇦 investigators #CCR24 #REVISEtrial #CYCLEtrial #HEMOTIONtrial
Brilliant work from Michelle Kho, PT, PhD, Heather O'Grady & the whole #CYCLEtrial team at #CCR24 📌Early in-bed cycling+physio vs physio alone in MV pts did not improve physical function 3d after #ICU discharge 📌Physio is CRUCIAL in #critical illness to avoid functional #disability
bronwen connolly has suggested that dose could be teased out by looking more closely at the amount of passive vs partially active vs active cycling performed. #CYCLEtrial #CCR24
The #CYCLEtrial has been simultaneously published in NEJM Evidence doi.org/10.1056/EVIDoa… CYCLE Funders - CIHR CFI / FCI Accelerating Clinical Trials Canada
ICU-aquired weakness remains a major problem in our criticall ill/mechanically ventilated patients. Even though the #CYCLETrial didn't show benefit*, Prof Carol Hodgson highlights importance of rehab in general & the high level delivered in this trial. #CCR24 Critical Care Reviews
Perhaps the #CycleTrial showed no difference because of excellent physiotherapy in the comparitor group. Is cycling something that could be safely delivered by RNs or other non-PT support staff? If so, this could be game changing in PT-deficient centres. #CCR24 Critical Care Reviews
Prof Carol Hodgson is editorialising the #CYCLEtrial and points out: - Unclear whether passive cycling (vs partially active or active) has any benefit. - Dose of cycling was low. - Constant resistance was used - Dose of usual physio was higher than in average ICU #CCR24
Michelle Kho, PT, PhD, in the context of #bling3 showing late separation between groups, do you think that 3 days post ICU discharge might have been too early a timepoint in the #CYCLEtrial? #CCR24
Cycling. Looks like it still benefits ICU/EM consultants more than it does their patients. No difference in clinical outcomes at any time point. #CycleTrial Amazing work and powerful presentation by Heather O'Grady, Michelle Kho, PT, PhD, & their collegues.
Primary outcome of #CYCLEtrial: no difference between groups (nor in sub-groups) in physical function outcomes, at 3 days post ICU discharge. #CCR24 Michelle Kho, PT, PhD
The #CycleTrial has me drawing parallels between astronauts & ICU pnts. Hear me out. Both lose muscle mass/fx exceptionally fast. Both could attenuate this with active exercise. Both are highly studied groups, now with cycling studies. #CCR24 Critical Care Reviews Heather O'Grady Michelle Kho, PT, PhD
Michelle Kho, PT, PhD is presenting the #CYCLEtrial: 30mins of in bed cycling + usual physio for 5 days/week vs usual care, for ICU pts. Primary outcome: physical function test 3 days post ICU discharge. Included pts within 4 days of MV and within 1st week of ICU admission. #CCR24
#6 #CYCLEtrial 📌Early In-bed Cycling for Mechanically Ventilated Patients 👥360 pts 🔀Arms: In-Bed Cycle Ergometer (30 min/d) vs Routine PT ➡️Primary outcome: Physical Function Test for ICU-scored at 3d after ICU discharge 🔗 doi.org/10.1136/bmjope… Michelle Kho, PT, PhD #CCR24 7/8
