John Wallingford It seems to me that there are situations, like the one Thibaut Brunet mentions where it helps. We have the same w/ #gastruloids where by default there's no #morphogenesis but you can't have a discussion on that topic w/o cell or dev biologists!

We are present at the #spemannmangold2024 symposium in Freiburg, impressive talks with a great lineup of speakers. If you are interested in hearing about our work in #gastruloids, stop by posters 2.19; 2.29; 2.36 and 2.38!

Richard Harland John Wallingford Well, mammalian ones; however there are differences; #gastruloids are #selforganied for more on this multicellular behaviour elifesciences.org/articles/59371 Lenne Lab Much to discuss but yes, surprising.

💫NEW: Hamazaki, Yang et al. report that an early pulse of #RetinoicAcid induces human #gastruloids with a neural tube, segmented somites and more advanced cell types than conventional gastruloids. #embryo_models wei yang Nobu Hamazaki Jay Shendure nature.com/articles/s4155…

Deluge of useful information @ proteomics, protein/mRNA correlations, comparative molecular landscapes and more. #gastruloids (#mouse and #human) biorxiv.org/content/10.110… Valuable resource. Huge effort from Devin Schweppe Nobu Hamazaki and colleagues #EmbryoModels #InNumbersWeTrust

#Gastruloids have many uses as #models for: early mammalian development, #SelfOrganization, mapping signalling/gene expression, morphogenesis. Here Lenne Lab use’m to develop gral tools to image gene/protein expression at diff scales biorxiv.org/content/10.110… #InNumbersWeTrust

Exposing lab-grown models of early human development –  #gastruloids – to #retinoicacid makes them more faithful mimics of implanted #embryos. Image & research by Nobu Hamazaki & Wei Yang et al Jay Shendure lab UW Genome Sciences in Nature Cell Biology. Links, search on bpod.org.uk/archive/2024/8…

#Retinoic acid induces human #gastruloids with posterior #embryo -like structures | ⁦Nature Cell Biology⁩ ⁦Stylianos Lefkopoulos (he/m)⁩ Interesting work from ⁦Jay Shendure⁩ and colleagues ! nature.com/articles/s4155…

🧪 A research team led by Dr. Nobu Hamazaki shows that an early pulse of retinoic acid, together with later Matrigel, robustly induces human #gastruloids with posterior embryo-like morphological structures, including a neural tube flanked by segmented somites and diverse cell

Assessing the role of signalling in cell diversity & organization w/ extended human #gastruloids + a useful computational comparison across species and #EmbryoModels Jay Shendure @VInetteY Nobu Hamazaki et al nature.com/articles/s4155… #Wnt #BMP #InNumbersWeTrust

🥂Congratulations to Jay Shendure, wei yang, Nobu Hamazaki & co for their new Open Access study in our journal (Nature Cell Biology): an early pulse of retinoic acid induces human #gastruloids with a #NeuralTube, segmented somites and more advanced cell types. nature.com/articles/s4155…

Compelling work on Hox13 paralogs role in axial length in mouse Denis Duboule group biorxiv.org/content/10.110… & demonstration of the value of #gastruloids as a model to provide evidence for good questions. + proof of how DNA space is read as time in #Hox gene expression #InHoxWeTrust

Hoxb13 and the control of body length, with #gastruloids to the rescue and #CTCF as heterochronic factors🕰️now in bioRxiv biorxiv.org/cgi/content/sh…🤘A long-lasting project with many colleagues to thank🙏and congratulate!👏 the Node CTCF Papers 📚

If you want to know more about #gastruloids and see how they can be used to look at #embryos in a manner that embryos don't let you #ISSCR2024 poster 575 Joshua Frenster #CellCompetition

Using #Gastruloids to study mammalian #CellCompetition. Hello world, Poster 575 is ready for you. (And thank you ISSCR for the merit and travel awards!) #ISSCR2024

Thank you Michele Boiani for the invitation and the opportunity to introduce the possibilities of #gastruloids to ESHRE community.

Farewell to #ASCB INSTITUT PASTEUR. As always, a stimulating few days and great to have a whiteboard to scribble on. Leave behind David Turner peering on the magic of #gastruloids. Thank you Tajbakhsh lab Bally-Cuif ZenLab , the staff, the students and, bien sure, Paris! A bien tot

On my way to BaCell3D. Such a beautiful place. Excited to hear about 3D developmental systems and talk about #gastruloids and #cellcompetition! Poster 220 ;)

Ingenious use of data analysis from Naama Fa Iftach Nachman lab to dip into the dynamic requirements for Nodal and mechanical signalling during mammalian endoderm specification using #gastruloids shorturl.at/xcy1j