Using single-cell and spatial transcriptomics data, FlowSig provides a unified signaling modeling framework by connecting intercellular communication mediated by ligand-receptor interactions and intracellular gene expression modules. nature.com/articles/s4159…

Automated molecular optimization of a BRD4 inhibitor using #AlphaFold predicted structure with our new #GenerativeAI drug design method, DrugHIVE. paper: pubs.acs.org/doi/10.1021/ac… GitHub: github.com/jssweller/Drug… Remo Rohs lab USC Dept. of Quantitative & Computational Biology. JCIM & JCTC Journals. #compchem #machinelearning

New findings from LiuLab_Rockefeller provide insight into a master regulator of gene expression, and could open up new avenues for Rett syndrome therapies. #RockefellerScience rockefeller.edu/news/36409-new…

Exicted to share our recent work using protein structure prediction to characterize the function of viral proteins led by the brilliant Jason Nomburg!

Prof. Nikolai Slavov The researchers in this study wanted to understand how proteins can have different amino acids than expected based on the genetic code. This can happen when the messenger RNA (mRNA) is translated into proteins in a way that deviates from the normal rules. The researchers

"Lipids on the move": Thank you to Nature Chemical Biology for highlighting our latest #lipidtime work using #bioorthogonal chemistry to image rapid, inter-organelle lipid transport, by Lin Luan, Dongjun Liang, and Reika Tei in #ACSChemBio! nature.com/articles/s4158… pubs.acs.org/doi/full/10.10…

Thrilled to share our latest story Nature Cell Biology on a new way to control protein localization without exogenous triggers (e.g., light/rapamycin)—take advantage of endogenous triggers in dividing cells! Free link: rdcu.be/dSlrS Regular link: nature.com/articles/s4155… 1/4

New article in Nature Communications by J.-E. Bredfeldt, J. Oracz, K.A. Kiszka et al. "Bleaching protection and axial sectioning in fluorescence nanoscopy through two-photon activation at 515 nm". Open access at nature.com/articles/s4146… MPI for Multidisciplinary Sciences #Optics #Imaging #Microscopy #STED

Paper alert! First high-res endogenously (blended) purified C elegans Ribosome SPA structure is out RNA Thanks PNCC for all the (once again!) outstanding support! rnajournal.cshlp.org/content/early/…

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/

#cryoEM with energy filter & electron counting significantly increased resolution even for a full size protein like proteinase K. Sub-atomic resolution #MicroED rivals best reported Xray of Proteinase K but by using crystals a billionth the size. A section of the map is shown

just for the pleasure of it, the fine choreography of epithelial cell migration with a PI3K mutation. This is the complex behavior we have to drug to treat cancer ... Movie from Lucien Hinderling . Switch sound on.

🔔🔔🔔FACULTY POSITION IN OUR DEPARTMENT UC San Francisco 🔔🔔🔔 We are scientifically diverse, spanning a huge range of basic sciences! Bioengineering, Computational Biology, Drug Development Sciences, Molecular Design, Systems Pharmacology, ANYTHING QUANTITATIVE! aprecruit.ucsf.edu/JPF05232

Interested in starting an independent research group? We're looking for two group leaders in the Genome Biology Unit at EMBL Heidelberg. Don't miss your chance to apply by 8 September! More information: embl.org/jobs/position/… embl.org/jobs/position/…

My department seeks to hire a new tenure-track assistant professor in computational biophysics, broadly defined, to complement and grow Notre Dame's existing biophysics community. Please share -- and consider applying! apply.interfolio.com/152715

👏 A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors. nature.com/articles/s4146…

Wow! So pretty ! Bravo!

Beautiful work on the in situ structure of ATP Synthase by Lea Dietrich from the Kühlbrandt group published today in Science Magazine 🔬 Discover how this important protein complex shapes the inner mitochondrial membrane! 🧪 science.org/doi/10.1126/sc…

Faculty search in neuroscience (broadly defined) in Biology dept at Stanford! Come and be my colleague! We are interested in ALL areas of neuroscience including structural, molecular, cellular, developmental, systems-level, computational, and technology development.

Amplifying our open faculty position UC San Francisco in the Department of Bioengineering and Therapeutic Science aka BTS, a basic science department with an engineering/quantitative bent with a plain text link to the position: aprecruit.ucsf.edu/JPF05232 details in thread below!