#DidYouKnow our body 'eats' itself to stay healthy? Our cells break down and recycle their own contents in a process called autophagy. In the 90s, Yoshinori Ohsumi discovered how autophagy worked, helping us understand how it protects our body against disease.

#NCRISImpact: In a step forward in #dementia research, SAHMRI's Dr Dr Tim Sargeant and Dr Ed Robins are pioneering a PET scan to visualise the brain’s self-cleaning process, potentially preventing Alzheimer’s. Read the full story: sahmri.org.au/news/research/… Australian Government Department of Education

"Pay for Open Access, I don't care how much it costs"

"This infection — the commodification of scholarship, the industrialisation of cheating — has now spread to the heart of scientific, higher research" abc.net.au/news/2024-05-2…

Good to see our methods article out Journal of Mammary Gland Biology and Neoplasia. We hope the #lysosome enthusiasts find it useful! It was great to work with Christine J Watson, Dr Tim Sargeant and Michael D'Angelo again, with valuable contributions from Neve Prowting School of Cellular and Molecular Medicine🏳️‍🌈😷 and Beth Wiseman Bristol Biochemistry

And we're on the cover The EMBO Journal! Well done Claudia Carabaña for this beauty👏 Silvia Fre Institut Curie School of Cellular and Molecular Medicine🏳️‍🌈😷

Protocol for a randomized cross-over study measuring the effect of reduced protein intake on autophagic flux in healthy adults medrxiv.org/cgi/content/sh… #medRxiv

Delivery delivery delivery... getting #lysosomal proteins into the brain is proving promising for #neurodegenerative disease and lysosomal storage disorders - more great work appearing on Alzforum How to Get Enough Progranulin into the Brain? alzforum.org/news/research-…

Great read from academics who are fighting back against the train wreck that is the current open access publishing model - Academic journals are a lucrative scam – and we’re determined to change that | Arash Abizadeh theguardian.com/commentisfree/…

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It had to be done

We’ve worked out how the molecular machines that create acidic compartments can recruit autophagy (self-eating) machinery when they can’t maintain a pH gradient. We are really pleased with this discovery, out in Molecular Cell cell.com/molecular-cell…. 1/16

New paper from our lab: Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta; Nature Comms ⁦Sanuri Liyanage⁩ ⁦SAHMRI Heart⁩ ⁦SA CVRN⁩ ⁦AAS⁩ ⁦SAHMRI⁩ nature.com/articles/s4146…

Imagine if this funding were instead used to ensure the sustainability of research and secure academic jobs.

The Rapamycin & Exercise clinical trial protocol is now available as a preprint. All comments/feedback welcome! (there are no conflicts of interest to declare) researchsquare.com/article/rs-472…

Excited to share that our chapter in the book 'ATG8ylation and Its Manifestations' is now published, co-authored with Dr Tim Sargeant ! Big thanks to Vojo Peter Deretic for the opportunity to contribute to this work! cambridgescholars.com/product/978-1-…

Our latest preprint! Some beautiful cell biology in this one. "Presynapses are mitophagy pit stops that prevent axon degeneration" biorxiv.org/cgi/content/sh… Discoveries into the cell biology of of mitophagy in axons, a disease mechanism, and a potential therapeutic avenue. 1/2

Our paper about how autophagy changes in mice as they age and in response to a high-fat diet is now available on bioRxiv. Big thanks to Dr Tim Sargeant & team, as well as SAHMRI & The Hospital Research Foundation Group ! biorxiv.org/content/10.110…