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Ok I am pleasantly shocked (in this country) and impressed @ uber

Congratulations to Drs. Glazar and Bekker! 🚀 Always a pleasure to visit IMO and catch up with science friends over invigorating discussions.

Here’s a paper that will get zero press because it looks totally specialist, not to say obscure. It’s about how an important class of transcription factors regulate genes. But I think it's worth dissecting because it raises a wider question.Bear with me... pnas.org/doi/10.1073/pn…

I am delighted to announce that we are hosting the 9th SoCal CryoEM Symposium, Oct 11th 2024 USC USC Bridge Institute in LA. We are especially excited about our keynote speaker - the one-and-only Prof. Hao Wu Prof. Hao Wu. Registration is free. Spread the word! dornsife.usc.edu/bridge-institu…

Two new preprints from my group today---this one was led by Dandan Peng with an assist from Obadiah Mulder. Dandan benchmarked a bunch of leading ARG-estimation methods with respect to a specific goal (1/n)

The 2nd Diversity of Math Bio Summer Virtual Seminar Series starts TOMORROW, June 4! This SMB - Society for Mathematical Biology series highlights the diversity of mathematical biology research and the diversity of researchers in the field. Tuesdays at 8:00 PDT / 11:00 EDT / 17:00 CEST via zoom.

when did mechanism become such a dirty word in science?

We are on the cover of Cell Systems! Cool collaborative paper led by the brilliant Maximilian Strobl with Cancer Ecology and Evolution Lab: CEEL Philip Maini Robert Wenham Jeffrey West Jill Gallaher Mark R-T The Gatenby Lab. A special shout out Centre for Evolutionary Therapy for partially funding this project! IMO Moffitt Cancer Center

The term "foundational" is supposed to mean subsequent models can be built on the model. This excellent analysis suggests otherwise. TBH, I cannot see any model in biology, at current data density, being "foundational", so can we stop using this?

Last day to apply to a postdoc in ML in my group. If you like digital pathology / spatial transcriptomics / computer vision and even genetics(!) please apply: careers.humantechnopole.it/o/postdoc-in-m…

There was a limit of 50 papers at journal we recently submitted to. Our paper had 92 refs in biblio. I argued that since our paper was "half mathematical and half biological" (in itself nonsensical of course) they ought to double the limit... ...it worked.

President Venn Diagram xkcd.com/2962

Thanks for hosting Leibniz-Institut für Alternsforschung (FLI) and KL Rudolph lab, had a fantastic visit to the FLI. There's a lot of exciting science happening in these green hills of Jena.

Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n) Link: doi.org/10.1101/2024.0…

god I love it when you get to the last paragraph of an Introduction and it says "The remainder of this paper is structured as follows." non-theoretical/mathematical biologists should LEARN THIS TRICK and use it always.

stem more, stem more, stem more, stem mooooorre doi.org/10.1182/blood.…

Hematopoietic stem cell aging by the niche Commentary w KL Rudolph out now in Blood Journal. This was fun to write! Exciting work from Jennifer Trowbridge answers the question of whether MSCs are actively involved in HSC aging... and raises many more. ashpublications.org/blood/article/…

phew, 3.5yo can be unsparing on a Sunday morning jaunt [loudly & audibly as we slowly bike past a runner] dad, that man is running very very slowly Why is he running so slowly? Maybe he is sick? He also needs sunscreen. I hope he's running home to his mommy to get his sunscreen.

Some fascinating insights into the interplay between MSCs and HSCs. Thanks for sharing! 👀

I just had another of those first days. I love this tweet so---for it gives us all space to be nervous on the first day of classes. If Steve (who literally wrote the book on it) is, then we too are allowed to be nervous on each first day.