Twitter Beğeni Hilesi

onlinelibrary.wiley.com/doi/10.1111/jt… strong work by all, great team of co-authors and collaborstors! Stay tuned for more (and better), coming soon! Have to innovate our way out of this pandemic BIDMC Department of Surgery BIDMC Anesthesia, Critical Care and Pain Medicine

apnews.com/5c0dc863f214d3… our ideas are starting to gain traction...and work! Best dosing TBD in our Phase 2a, coming soon! Bloodman BIDMC Department of Surgery BIDMC Anesthesia, Critical Care and Pain Medicine Shaz Shaefi Ryan Radecki, MD MS

can anyone help get FDA moving? IND's for potential coronavirus therapies supposed to take days, not weeks/months! CNN Breaking News Dr. Sanjay Gupta CBS News ABC News The New York Times

onlinelibrary.wiley.com/doi/10.1111/jt… Our response to ISTH guidance on COVID-19 coagulation management. Worth a read. In the absence if an RCT, the unknown has to be treated by clinical observation and clinical reasoning. Our take: anticoagulate early and aggressively. BIDMC Department of Surgery

FDA just issued our IND to start our Phase 2 multi-center RCT of tPA in COVID respiratory failure! Finally!! Stay tuned...

Dolhnikoff et al last month in JTH: 8 of 10 autopsies with diffuse pulm microthrombi in COVID. Ackermann et al last week in NEJM: 10 of 10 autopsies with diffuse pulm microthrombi. Fox et al in Lancet Resp Med yesterday: 10 of 10 with diffuse pulm microthrombi. Its clear, need AC

cnn.com/2020/07/10/hea… Hard to understand why people are more comfortable watching the natural history of disease while awaiting RCT's to finish. It is a clotting disorder...if it weren't, why do otherwise healthy people show up with presenting symptom of thromboembolic stroke?

One of my fav projects w/ Hunter Moore CU Department of Surgery , still refining, but dichotimizes risk 4 massive transfusion & hyperfibrinolysis in trauma in 5 mins! (& now doing study w/ACT machines in trauma & liver txp 2 get answer in ~2-3 mins thx 2 @ILWorldwide ), journals.lww.com/jtrauma/Abstra…

"These failures reflect a “perfect storm” of governmental ineptitude, scientific ignorance/misprioritization, and the abdication of medical training to market-driven forces." A stinging editorial that is spot on. stke.sciencemag.org/content/13/649… Science Signaling by Michael Yaffe and Christopher Barrett M.D.

stke.sciencemag.org/content/13/649… Editorial by Michael Yaffe and myself came out in Science Signaling today on the shortcomings in our scientific and medical response to COVID-19...check it out if you get a chance BIDMC Department of Surgery Koch Institute at MIT

On the latest #TWiV Daniel Griffin's #COVID19 report including role of vitamin D, Michael and Christopher explain why we have made all the wrong moves during the pandemic, evidence that D614G improves transmission in hamsters, and listener questions bit.ly/3ivQ65i

check out This Week in Virology with guests me and Michael Yaffe discussing the missteps and misprioritization in our National COVID-19 responses, from medicine to science to government. Thanks Vincent Racaniello for having us! microbe.tv/twiv/twiv-669/

great paper by RutgersPulmonaryCriticalCare Sarah Orfanos, Jared Radbel et al showing reduced dead space ventilation with tPA dosing in COVID ARDS! Response was best with early use after intubation and in those with highest levels of fibrinogen...great work! bit.ly/2GdM44a

To honor our beloved colleague & friend, we established the Khalid Khwaja, MD Faculty Award, which will be given annually to a jr. faculty member who fosters what Dr. Khwaja stood for: collaboration, respectfulness, compassion & a shared sense of purpose. bit.ly/37STzcA

a refugee blown out to sea by a typhoon at age 9, survived, came to US, then became a US Army Ranger and 3rd BCT 25th ID Command Sergeant Major, somebody should make a movie out of this guy's life. Its truly an incredible story of America at its best home.army.mil/hawaii/index.p…

On Monday we finished enrollment in our multicenter Phase 2a RCT "STudy of Alteplase for Respiratory failure in Severe acute respiratory syndrome coronavirus 2/COVID‐19" (The STARS trial, NCT04357730)...study design described in onlinelibrary.wiley.com/doi/full/10.10… stay tuned for results!

journal.chestnet.org/article/S0012-… Our tPA trial for COVID is out! Thx to all! tPA bolus group with significantly improved oxygenation. 12 less days on vent (12 more VFD) & half mortality in tPA bolus group, signal persisted at each interim, need larger N to eval for significance. No ICH!

thieme-connect.com/products/ejour… great to get this update on role of viscoelastic assays across ALL phases of trauma care out with Jonathan Meizoso, MD, MSPH, FACS Hunter Moore Ernest E Moore MD need to get a meeting put together to standardize indications for use Jan Hartmann, MD

Thanks to Robert Medcalf and Prof. Yukio Ozaki for the opportunity to be an Associate Editor Thrombosis Journal , excited for the future of the journal!

Exciting work presented by Elizabeth Maginot, MD at AAST! AAST Christopher Barrett M.D.