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Yep, interesting work from the Levitz lab and yet another fantastic opportunity for the Filizolalab to collaborate with them Nature Communications . Special thanks to Alexa Strauss for plowing through with grace and optimism.

Wang et al. reveal that tricyclic and tetracyclic antidepressants can acutely inhibit but ultimately 🆙 VMAT2 activity by promoting protein maturation, suggesting potential therapeutic benefits for mood disorders. nature.com/articles/s4138…

Here we go! Our structure of the human dopamine transporter in complex with cocaine has been published in Nature (nature.com/articles/s4158…). Commentary by Harald Sitte (nature.com/articles/d4158…). Thanks to Azadeh Shahsavar and Pape for contributing. Department of Neuroscience, UCPH, UCPH Healthscience

Can AlphaFold be useful in drug discovery? Hell yes! In our paper, structure-based virtual screens using AlphaFold models identify potent GPCR ligands with antipsychotic effects in vivo (science.org/doi/10.1126/sc…). KAW Uppsala University Karolinska Institutet SciLifeLab

Honoured to have been elected to serve on the Biophysical Society council. Congratulations Karen Fleming Dr. Theanne Griffith 🇧🇧👩🏾‍🔬🇭🇷 SILVIA CAVAGNERO Ryota IINO 飯野亮太 Samantha Harris on your election! Looking forward to working with you and the rest of Council over the next few years.

The first cover of a journal from the lab! Thanks The EMBO Journal for featuring the collaborative work with Dr. Robinson lab. Congratulations to Imoto lab for this beautiful image and work!!

Comprehensive and comprehensible review on #GPCR drug discovery by Terry Kenakin (the guru of quantitative pharmacology) nature.com/articles/s4157…

Astrocyte Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice: Neuron cell.com/neuron/fulltex… Congrats to Joselyn, Chiran and the whole team on this one!

Frizzled receptors are essential for all multicellular life, from hydra to humans. Please check out our new paper on how we used nanobodies to elucidate the structure and function of Frizzled 3: nature.com/articles/s4146…

Woohoo, our paper on the mechanism of a G protein inhibitor that is specific to one family of G proteins is out! Nice collab with the Blumer nad ASoranno labs pnas.org/doi/10.1073/pn…

I'm happy to finally present our #cryoEM work on Voltage-gated sodium channel 1.8 (Nav1.8) with a bound Tarantula peptide Protoxin-I!! Fabulous work from Bryan and Stephen 🥳🎉👌 biorxiv.org/content/10.110…

How does the hERG channel inactivate so rapidly. Our latest paper on the #CryoEM structure of an inactivated hERG channel is out now in Nature Communications Read here: rdcu.be/dSkIY Victor Chang Cardiac Research Institute

Why are smokers protected from Parkinson's disease? Have we been looking at the wrong element in smoke? Nicotine instead of carbon monoxide? Rose, Gomperts and colleagues nature Parkinson's Journal show that there was neuroprotection w/ low dose carbon monoxide in Parkinson’s

How to sense danger from afar? Revised and refined, our paper on the insights into smell recognition by a mammalian trace-amine receptor from Cryo-EM, modelling and functional studies is finally out! nature.com/articles/s4146…

nature.com/articles/s4159… We are excited to share our latest research on the structural and functional mechanisms underlying anti-NMDAR encephalitis. Our study reveals that three antibodies, isolated from different patients, bind to distinct regions of the NMDARs 1/n)

Delighted to get this out!we describe bitopic binding mode to the dopamine 3 receptor, including a reorganization of TM1 that generates a unique site that could be exploited to develop selective molecules. Tremendous effort from Sandra Arroyo Urea Angela nature.com/articles/s4146…

This is really a stunning paper. Cyanobacteria exposed to shorter days (in the lab) "rewire" their membrane lipids to anticipate cold weather. When those cells are plunged into cold water, they have "two or three-times higher survival" than cells exposed to longer days.

Congrats, Javier! Great to see it out.

Cell swelling enhances ligand-driven β-adrenergic signaling 浸透圧により膨張した細胞において、アルGPCRが『好む構造』を取るかもと言うお話。膜の厚みの微妙な変化が機械刺激応答でないと考えられる膜タンパク質に影響与えててもおかしくは無さそうだな nature.com/articles/s4146…

1/5 Happy to share our new preprint with co-first author Meghna Gupta biorxiv.org/content/10.110… Stroud Lab, MGupta Lab, James Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Eng, Tomo Kawate, Sree Ganesh Balasubramani, Andrej Sali lab, Deborah Hung, Robert M. Stroud Robert M. Stroud.