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Hot off the presses: New paper in Addictive Behaviors, with Dana Rubenstein, MHS and Joe McClernon. Using NSDUH data, we found an increasing prevalence of tobacco and cannabis co-use overall and among most sociodemographic strata over time in the US. 🔗:sciencedirect.com/science/articl…

Groundbreaking research in Biological Psychiatry using #fMRI analysis uncovers a link between #cognition & #brainnetworks prior to #psychoticbreak in those at risk of #psychoticdisorders spkl.io/6016f6p66 Society of Biological Psychiatry @Els_Psychiatry Roscoe Brady Heather Burrell Ward, MD Eve Lewandowski

Biological Psychiatry Robust Brain Correlates of Cognitive Performance in Psychosis and its Prodrome biologicalpsychiatryjournal.com/article/S0006-…

📢 Exciting news! We’re organizing the second #ISMRM Workshop on MRI of #Neuromodulation. We’d love your suggestions and welcome volunteers for organizing or speaking. Please take a few minutes to complete our survey 👉 link.webropol.com/s/mriofneuromo…

Amazing work, Walid! 🤩

Brain Wide Association Studies (BWAS) offer a data-driven approach to link brain network organization to clinical phenotypes.. ..but there’s evidence that reliable BWAS requires sample sizes in the *thousands*. This concern even got some news coverage.. (2/13)

For researchers working with clinical populations (as we do), imaging n=1000s would be an enormous challenge. BUT.. what if the unreliability of BWAS in small samples wasn’t inherently a “MRI problem” that could only be overcome with thousands of scans? (3/13)

We theorized that non-specific measures like IQ don’t reliably map onto brain structures except in weak associations (i.e. n=thousands).. but cognitive tests of more specific cognitive constructs and tests tailored to specific populations could overcome this limitation.. (4/13)

We tested this theory in our study of cognition in psychotic disorders. Cognitive deficits are linked to significant disability and are already present by the time these disorders are diagnosed, making early identification a priority. (5/13)

Using data from the Human Connectome Project-Early Psychosis (HCP-EP), We analyzed performance on the Seidman ACPT, a measure of attentional performance specifically designed for individuals either diagnosed with psychosis or identified as being at risk for psychosis (6/13)

We searched for resting-state connectivity correlates of ACPT performance using a BWAS approach that is parcellation-free i.e. without assumptions about network topography (7/13)

We observed that the strongest correlate of ACPT performance was functional connectivity between prefrontal cortex and somatomotor cortex. This relationship was specific to the individuals with psychosis and was *not* observed in controls (8/13).

If these cognitive deficits are present even prior to diagnosis then we reasoned that this brain connectivity result should also be observable in at-risk individuals prior to diagnosis. To test this we turned to the North American Prodrome Longitudinal Study (NAPLS) (9/13)

NAPLS enrolled hundreds of individuals identified as being at risk for psychotic disorders, collected MRI and cognitive data including ACPT and followed them longitudinally for two years to identify which individuals would go on to be diagnosed with psychosis. (10/13)

We were thrilled to observe the same connectivity-cognition relationship in individuals at-risk for psychosis. This relationship was *specific* to Individuals who would eventually convert to psychotic disorders and was not observed in non-converters or controls (11/13)

Enormous thanks to the participants and investigators of both HCP-EP and NAPLS; to National Institute of Mental Health (NIMH) for funding; to the reviewers, staff, and editors at Biological Psychiatry ; and to our home institutions BIDMC, Vanderbilt Psychiatry, and McLean Hospital (13/13)

Beyond excited to share this new paper in Biological Psychiatry identifying 🌟reproducible🌟 brain correlates 🧠of cognitive performance in psychosis that is the product of years of work, 27 coauthors 🥵, and the unparalleled mentorship of Roscoe Brady

.Vanderbilt Health and OHSU News have been awarded funding from the National Institutes of Health to establish a K12 program to train scholars in addiction research. COSTAR is the newest among seven currently funded NIDAnews K12 training programs. bit.ly/4gdvpKA

School shootings are not just a fact of life. It doesn’t have to be this way. We can take action to protect our children—and we will.

Had so much fun talking about cerebellum, psychosis, circuits and magnets with ⁦StoodleyLab⁩, ⁦Hengyi Cao⁩ and ⁦markhalko⁩ at the ⁦LMU Klinikum München⁩ #ECSR2024