Twitter Beğeni Hilesi

i obtained documents showing that a key feature of new york’s vaccine passport app wasn’t really being used vox.com/recode/2273627…

i investigated the autoplay feature on YouTube Kids vox.com/recode/2241223…

Type 2 neuroimmune circuits in the shaping of physiology cell.com/immunity/fullt…

It’s alive on BioRxiv! Super excited to present our paper on CRISPRi-based screens in 3D neuron-astrocyte-microglia co-culture (iAssembloids) to examine neuron-glia interactions. Description of this work in the thread below! Too many words! (1/8) biorxiv.org/content/10.110…

Stress induces behavioral abnormalities by increasing expression of phagocytic receptor, MERTK, in astrocytes to promote synapse phagocytosis: Immunity cell.com/immunity/fullt…

IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy: Cell Reports cell.com/cell-reports/f…

John Lukens Is chronic social defeat like getting your grants unfunded over and over again?

Human microglia maturation is underpinned by specific gene regulatory networks: Immunity cell.com/immunity/fullt…

This is truly a tour de force I could not have been more proud to contribute to! Check out this truly immense and impressive work put out by the soon-to-be Dr. Littleton!

biorxiv.org/content/10.110… Super happy to announce the culmination of a super fun and interesting project! TL;DR we observed an inverse relationship between the metabolic profile and strength of the circadian rhythms in cancer cells; which could aid in therapeutic interventions.

Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells biorxiv.org/cgi/content/sh… #bioRxiv

My functional validation of a causal variant at the FAIM2 obesity GWAS locus is out today in Cell Genomics! (1/4) cell.com/cell-genomics/…

We found that the rs7132908 obesity risk allele can switch an enhancer→repressor, modify nearby gene expression with FAIM2 consistently downregulated in multiple cell types, and decrease appetite-regulating neurons produced by ESC differentiation (2/4)

Our hypothesis is that FAIM2 is required for normal appetite-suppressing neuron development/survival during childhood and decreased FAIM2 contributes to increased obesity risk at a young age (3/4)

I’m so proud of this challenging work and must thank many contributors including Struan Grant Matt Pahl Alessandra Chesi Kieona Cook and amazing core facilities at Penn Medicine and CHOP Research (4/4)

Microglia transplantation therapy for treating neurodegenerative conditions doi.org/10.1016/j.neur… doi.org/10.1016/j.neur… Neuron

Finally out! Check out our new paper in Nature Communication 10.1038/s41467-024-49596-0. In this new study, we established that microglia make their own TGF-β1 ligand to maintain brain homeostasis and cognitive function via autocrine signaling mechanism at a single-cell level!

🚨 Registration is LIVE for our FIFTH annual Black In Neuro Week, happening this July 29-August 4th! We’ll have seven days packed with FREE programming that’s open to all. 🥰🧠 Register today!! ➡️ blackinneuro47.wildapricot.org/event-5771083

Microglia are the brain’s resident immune cells, and in neurodegenerative diseases they become dysfunctional. @Fchrisbennett is studying ways to re-engineer microglia so they reduce or prevent neurodegenerative disease instead of contributing to it 📸 Sonia Lombroso UPenn Pharmacology Graduate Group

Super Exciting Opportunity to do Super Exciting Work!