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Multi-omics network of Japanese (gut microbiome🦠 plasma metabolome🧪 host genome🧬) by YoshihikoTomofuji is now Cell Reports㊗️🎉. ABO blood type🆎 associate with gut microbial genes related to N-galactosamine metabolism. cell.com/cell-reports/f…

If you are in ACR 2023 @ SanDiego, please join the joint ACR-JCR session for human genomics (Wed 8:00am, 31A-C). 15W106: From Genotype to Phenotype: Towards Integration of Genetics and Clinical Medicine. cdmcd.co/B7dgJw

Looking forward to moderating the session of “From genotype to phenotype” We morning, and learning the cool things that YukinoriOkada found! #ACR23 🌟

Today, we discussed about a paper by YoshihikoTomofuji and YukinoriOkada on multi-omics analysis of host genotypes, gut microbiome and plasma metabolome. The main idea is to detect gut microbiome-host interaction through metabolites activities. 1/2 doi.org/10.1016/j.celr…

医学のあゆみ 特集「遺伝統計学の新潮流」が発刊されました。執筆頂いた皆様に感謝です。 amazon.co.jp/dp/B0CZ8SN3J4

Join me at #ESHG2024 for a talk on fatal lack of robustness of the pre-implantation genetic testing by PRS🤱🧬. Private companies have already marketed this testing to select embryos with ‘desirable’ potential. 📅7:15 PM on June 1 (Day 1) in Room A6+7. Hope to see you there!

Please join platform talks from our group at #ESHG2024 in Berlin🧬. Polygenic risk score (PRS)-based embryo selection strikingly differs across PRS construction methods with technical randomness, lead by Shinichi Namba 7:15 PM on June 1 (Day 1) in Room A6+7.

Our talk was featured in the press release by ESHG! #ESHG2024 eshg.org/news-home/for-…

💡Preprint alert! Polygenic risk score (PRS)-based embryo screening is strikingly unrobust across PRS construction methods with randomness. Huge thanks to the wonderful collaboration with clinical/basic/ELSI specialists medrxiv.org/content/10.110…

Tip to improve cross-population polygenic risk score (PRS)🧬transferability of type 2 diabetes (T2D): obesity-based patient stratification⚖️. Now Nature Genetics led by Takafumi Ojima & collabo with Biobank Japan Project (BBJ) and Tohoku Medical Megabank (ToMMo). nature.com/articles/s4158…

～今年の遺伝統計学・夏の学校は「応用編」～ We have "onsite" Summer School⛱️🏫of Statistical Genetics🧬at Univ Tokyo (Aug 31-Sep 1). Advanced English course on Polygenic Risk Score (PRS) analysis with Paul O'Reilly at Icahn School of Medicine at Mount Sinai. #gwas #PRS #omics sg.med.osaka-u.ac.jp/school_2024.ht…

Population-specifc common HLA & rare copy number variant (CNV) predispose unexplained recurrent pregnancy loss in females. Nice GWAS by Kyuto Sonehara & colleagues & Biobank Japan (BBJ)🧬 at Nature Communications. #GWAS #CNV #HLA nature.com/articles/s4146…

Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues dlvr.it/TBGLX6

"scLinax"🐧to quantify gene expression escape from X chrom inactivation with single cell omics by YoshihikoTomofuji is now Cell Genomics㊗️🎉. XCI escape is cell-type specific (e.g. lymphocytes) & modulates X chrom GWAS SNP effect size female-male difference!! cell.com/cell-genomics/…

Last chance to register for our PRS Workshop in Tokyo!! See details here -> sg.med.osaka-u.ac.jp/school_2024.ht… Please RT 🙏