Twitter Beğeni Hilesi

Come join us at EPFL! We are looking to fill a new position for a Tenure Track Professor in Chemical Biology! Find all info how to apply here: epfl.ch/about/working/…

New Assistant Prof position at Lisbon Univ - Evolutionary Biology euraxess.ec.europa.eu/jobs/266300

Happy to share that our #lipidtime work on the conformational dynamics of lipid transport proteins by Sriraksha Srinivasan Andrea Di Luca Daniel Álvarez and Arun John Peter is now out in PLOS Biology! Big thanks to collaborators Giovanni D'Angelo Charlotte Gehin Museer A. Lone for the support!

Exactly one year after the preprint came out (!), our revised manuscript on predicting epistatic interactions in SARS-CoV-2 is out in Genome Biology! We added experimental validations and a visual explanation of our samples weighting scheme (link in the next tweet)

Did AlphaFold solve the protein folding problem? ...Not yet! AF2 predicts static structures, usually the native state by default. However, we found AF2 can generate structures aligning well with known folding intermediates. biorxiv.org/content/10.110… Alberto Perez UF Chemistry 1/n

We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.110…

Three Kinds of Research xkcd.com/2977

It is still a bit early but I am co-organizing the next Nework Biology CSHL meeting (March 2025) and I am hoping that, among other things, it will be a great chance to think about the intersection of computational and experimental methods n this area meetings.cshl.edu/meetings.aspx?…

While I can't objectively rank our work against that of other teams it is easier to rank different projects from our group in my perception of value to others. This perception quite a lot of times does not match how it is received by editors/reviewers.

Dynamic PDB: MD simulations of up 1 microsecond for 12.6k proteins + an SE(3) diffusion model trained on MD data.

Ancestral Sequence Reconstruction is a powerful approach for inferring evolutionary trajectories. How powerful is it for young de novo sequences, though? academic.oup.com/gbe/article/16…

We've started IND-enabling studies on a small molecule corrector for Rho-associated autosomal dominant retinitis pigmentosa (Rho-adRP). I thought it would be fun to spend some time walking through our approach and why we are excited. Long 🧵1/

AlphaFold3 reproduced and params/code released. 🤩

What did women do to be so hated/feared?

Check out the brand new interdisciplinary EMBO | EMBL Symposium on Drug Resistance & Tolerance across organisms: Finding parallel concepts, mechanisms, and strategies despite different terminology EMBL Heidelberg on 18-21 Mar 25! #EESDrugResistance Link: s.embl.org/ees25-01

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

Big thanks to the European Research Council (ERC) for supporting my project #PTMtalk! Exciting times ahead for our team IBFG! #yeast 🥳 #ERCStG

1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in Science Magazine. science.org/doi/10.1126/sc… Here is a summary of what we discovered!

Deepmind white paper on protein design. I guess it is unclear if this is their version of preprints or if their new normal is white papers without detailed methods. deepmind.google/discover/blog/…

Consider starting a new research lab at vib.ai to solve big questions in life sciences using AI