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Check out our new preprint!

Thrilled to share my lab’s latest work, out recently in Mol Cell, on a role for HLTF in G4 resolution. Led by the amazing Gongshi Bai with essential contributions from @davidcortez, Brandt Eichman, Cejka Lab and The Boulton Lab. See: authors.elsevier.com/a/1jbBg3vVUPRm…

Interested in chromosomes, genetic syndromes and cancer? Check out our new review on Aneuploidy syndromes by Carolina Villarroya & Marcos Malumbres in Nature Reviews Genetics Vall d’Hebron Institute of Oncology (VHIO) CNIO Stop Cancer ICREA Community nature.com/articles/s4157…

Out in nature today! We report that a CDK5-cyclin B1 complex maintains proper cell division. We discovered that CDK5, a long regarded non-cell cycle CDK functioning only in neurons, yet overexpressed in many cancers, does regulate mitosis!  Link: nature.com/articles/s4158…

Excited to share the first review from our lab! We discuss the most recent findings on repriming from ssDNA gap formation to repair. Led by the amazing Tiya Jahjah and Jenny Singh with insightful contributions from Vanesa Gottifredi! sciencedirect.com/science/articl…

5/To produce meaningful discoveries, we need expertise in three areas: computational genomics, population genetics and mechanistic, disease-focused basic science. We will build in all three. Thanks to UT Southwestern Medical Center leadership for supporting this vision. -RJD

🚨📣 Excited to share our latest work investigating how the replisome responds to topoisomerase-DNA crosslinks 🧬🔬 cell.com/molecular-cell… Fantastic work from rosewesthorpe and Jonas 🍄🍄🍄🍄

Excited to share our work showing how PLK1 licenses CENP-A deposition at centromeres to ensure centromere inheritance WTCCB Cell Biology Gene Center Munich Biological Sciences | University of Edinburgh Universität München Pragya Srivastava Bethan Medina-Pritchard Alba Abad Paula Sotelo European Research Council (ERC) dhafer ben khalifa & MRC science.org/doi/10.1126/sc…

Very happy to announce this new publication from our lab: Role of protein kinase PLK1 in the epigenetic maintenance of centromeres | Science science.org/doi/abs/10.112… Kudos to Duccio Conti Arianna Esposito Verza Verena Cmentowski Dongqing Pan and Ingrid Vetter

Thrilled to announce our latest bioinformatic study in Nature Communications! If your interests are genome maintenance mechanisms in mitosis or DNA repair check out this rich resource of new genome maintenance candidates doi.org/10.1038/s41467… #dnarepair #replication #AlphaFold #Cancer

Aurora B kinase (green) distribution during initial cell divisions of a C elegans embryo relative to plasma membranes and nuclei (red), highlighting apical midbody remnants after cytokinesis. As seen by lattice light sheet microscopy. With Bembenek Lab doi.org/10.1242/dev.18…

Very happy to share our latest papers on the identification of novel dependencies of aneuploid cells just published in Nature Communications and Cancer Discovery!🧬A work jointly conceived by Ben-David Lab and Stefano Santaguida and beautifully executed by talented Johanna and Marica Ippolito 🧬 👇

Very happy to share our latest papers on the identification of novel dependencies of aneuploid cells just published in Nature Communications and Cancer Discovery!A work jointly conceived by Stefano Santaguida and the Ben-David Lab and beautifully executed by talented  Marica Ippolito 🧬 and Johanna

How can cells overcome and adapt to stresses induced by aneuploidy? If you are curious, check my two co-first author papers out! (2/2) #cancerdiscovery

I'm excited to share this collaborative work with Katerina Kraft and Matt Jones that started as an exploration of the nuclear organization of ecDNA in colon cancer cells and ended with some neat findings on repetitive elements. See thread for more!

Read Cancer Discovery's #ResearchWatch: The Fanconi Anemia Pathway Mediates Chromothripsis and Resistance to Cancer Therapy. bit.ly/4d350MW

Thank you Cancer Discovery for highlighting our work on chromothripsis! 🙏

Excited to share a commentary on emerging challenges in understanding and targeting cancer genome instability to improve patient outcomes: bit.ly/3XoSstk Thanks to Cancer Discovery for the opportunity and to everyone else from the AACR NextGen Stars Program who contributed!

We are happy to share our review on the 53BP1-mediated activation of the tumor suppressor p53. We summarize the cell cycle-depend functions of 53BP1 during mitosis and interphase and address its role in maintaining a healthy tissue. authors.elsevier.com/sd/article/S09…

We are thrilled to present you our work on BRCA1-BARD1 nature showing that the complex has a direct role in long-range DNA end resection. With Ilaria_Ceppi Maria Rosaria Dello Stritto and our collaborators Pablo Huertas' Lab Sylvie Noordermeer and Seidel labs. nature.com/articles/s4158…