New ‘Aging Clock’ Predicts the Maximum Lifespan of 348 Mammals Including Humans singularityhub.com/2024/06/07/a-n… via Shay Hub

Incredible DNA methylation predictors of mammalian life history traits.

Amazingly, an epigenetic signature intrinsic to a species predicts its lifespan.

Congratulations Prof Steve Horvath et al, one of the most mind-blowing discoveries I have ever seen🤯

science.org/doi/10.1126/sc…

Battle of the paper tshirts at GRC Systems Aging — Yamanaka vs. Horvath 🙂

(shout out to Nathan S. Cheng thinks you should work on aging.!)

Ahead of today's hearing in Congress: my opinion piece with the The New York Times on why Covid-19 was likely caused by a lab accident.

My hope since 2020 has been for leaders, especially scientists, to lead the charge in investigating a plausible lab #OriginOfCovid - as opposed to

Spent a big chunk of the last three months doing a tour of brain research labs and start-ups. At least half of them are not yet really known to the public. My conclusion is that we're about to increase our knowledge of how the brain works by many, many, many fold. As in,

Have been on deadline, so didn't have a chance to write on this. But, if you're into cell reprogramming (and who isn't?), you need to watch this preso from NewLimit and Brian Armstrong - because they seem to have made some major transcription factor discoveries

This is a very important question, and while Peter Fedichev📍dubai 🇦🇪 is a dear friend, on that question I strongly agree with Aubrey de Grey. Looking forward to their debate!

🚀 NewLimit’s progress update makes me even more optimistic that we can solve aging within our lifetime. The update addressed two key outstanding questions about partial reprogramming:

• Can we decouple rejuvenation from dedifferentiation?
• Can we get the rejuvenation to

Partial reprogramming looks more and more promising! Once we are able to fully harness its rejuvenating power, we could not only add many decades of healthy life, but potentially even reverse aging.

The two key outstanding questions for the field are:

• Can we decouple

Pretty amazing result — partial reprogramming with OSKM (Yamanaka factors) was observed to boost neurogenesis even in old brains:

I am actually a scientist myself, particularly focussed on collaborative science and getting people to work together, properly. That’s a large part of my job.

DRASTIC is a great guerillla group of experts set up by Billy Bostickson 🏴👁&👁 🆓, Yuri Deigin and others, that is doing incredible

Because I am mentioned six times in the first few pages of the Morens email dump, I wanted to provide some personal history re the #COVID19 origins issue in the thread below. 🧵

Indian Jumping Ant - workers live for several months, the Queen for years, but if the Queen dies a worker can be reprogrammed into a Queen, significantly extending it's life 🤯

This is a super interesting talk from Yuri Deigin on epigenetic cell reprogramming to slow or reverse