Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR dlvr.it/SyV30T

Delighted to share our latest paper led by the great Dali Zong- how inhibition of WRN helicase leads to cell death - and how dual targeting with ATR inhibition may be a useful treatment strategy- in microsatellite unstable cancers: pubmed.ncbi.nlm.nih.gov/37932011/

POLQ and Pol Delta are working together to synthesize DNA during DSB repair via MMEJ. 👏👏👏 Also explains how POLQ seals post-replicative ssDNA gaps on the lagging strand during replication, which I and others have previously observed. nature.com/articles/s4158…

It is out 😲 - 🥳 a tour-de-force by Nakatani-san + tremendous work from all co-authors - lots of exciting new biology - enjoy the reading 👇👇- looking forward to comments & feedback nature.com/articles/s4158…

doi.org/10.1016/j.cell…

What if we could inducibly create thousands of structural variants and ecDNAs in human cells and see which ones survive? biorxiv.org/content/10.110… I’m excited to share our story on scrambling the human genome by combining prime editing, repetitive elements, and recombinases. A🧵

ATR blocks telomerase from converting DNA breaks into telomeres | Science science.org/doi/10.1126/sc…

wow, big congrats!

A funded PhD position is available in the lab to work on how nuclear architecture influences DNA repair and genome instability. If interested, please DM or apply though the doctoral school web site : doctorat.campusfrance.org/CF202434553

Panday Lab Mayo Clinic is expanding and hiring a talented Post-doc. Please visit my lab website to learn about ongoing research on Genome Maintenance and Chromatin Plasticity in Cancer: mayo.edu/research/labs/… Please apply using following link: jobs.mayoclinic.org/job/rochester/…

Last year, we welcomed Andre Nussenzweig (andre nussenzweig lab, National Cancer Institute) for a Birnstiel Lecture - apologies for the delay, here is the long awaited recording of "Neuronal Genome Stability and Plasticity": 📺youtu.be/s9vd6tbgSXc

Check out this excellent opportunity using sequencing strategies to study genome integrity: replication, repair, genome organization and more.

Congrats! Great pics!

Huge congrats to Andre, Rapahel, Vennu and the others!

The Cortez lab (lab.vanderbilt.edu/cortez-lab/) is looking for new postdocs or senior scientists. If you are interested in genome stability, replication, DNA repair, or DNA damage responses please send me an email.

With their help, we found formulations of engineered nanoparticles that can efficiently deliver Cas9 into (iPSC-derived) postmitotic human neurons. And cut open their DNA. @JiaChen98369353 from andre nussenzweig lab lab took pictures of these Cas9-induced breaks in our neurons’ DNA.

Great collaboration with Giordano Reginato and Cejka Lab is now online at Nature Communications. Their findings that nickase Cas9H840A is removed from DNA by HLTF really helped us in our fork collapse story. nature.com/articles/s4146…

Now online! 5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming dlvr.it/TCfNJg