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Epigenetic systems are “famous” for stable propagation of gene expression states (memory). But these systems, e.g. regulating heterochromatin, can also be repurposed as a powerful mechanism for adaptation. New work with Kaushik Ragunathan (great Xtorial below)! authors.elsevier.com/c/1jWzg5Sx5gxl…

“ The resultant RNA molecules can be directly read via nanopore sequencing and can also be enzymatically computed to solve simplified 3 × 3 chess and sudoku problems. ” - in the meantime I can get my DNA to barely make protein 😂 fabulous work from Albert Keung

Can biased recruitment of histone variant determine transcriptional memory and response? Histone chaperone de-/acetylation dictates recycling versus de-novo deposition #chromatin #epigenetics #genes doi.org/10.1101/2024.0… TIFR India TIFR Hyderabad

Histone residue substitutions are always a treat. The multiomic characterization looks very interesting.

Share link: authors.elsevier.com/a/1jjHML7PXqRgc

I'm excited to share this collaborative work with Katerina Kraft and Matt Jones that started as an exploration of the nuclear organization of ecDNA in colon cancer cells and ended with some neat findings on repetitive elements. See thread for more!

Spectacular work fearlessly spearheaded by Narlikar/Ramani & Tetrad graduate student Camille Moore; check out & RT Camille's thread below describing her efforts to characterize chromatin condensation & some ways it can be regulated; bioRxiv here: biorxiv.org/content/10.110…

How are conflicts & R-loops rapidly resolved ahead of actively progressing forks? Is there a remodeler that associates with active forks, binds directly to R-loops, and senses & suppresses them? Check out our new study here!👇

📢It's a big milestone for the Lee lab - our very first preprint!!! 🥳 Grad student Deepshi A led a team of undergrads to ask how germ cells handle DNA damage with nucleosomes crowding the way 🚨 hint: 🚧NuRD remodeling clears a path for DSB repair🚧 biorxiv.org/content/10.110…