How to use #CRISPR gene editing to fight heart disease, the #1 killer worldwide: A thread 10+ years in the making. This one starts in 2009 when I was a postdoc in Sek Kathiresan MD lab MassGeneral News/Broad Institute studying ❤ risk factors like cholesterol & triglycerides. (thread)

Individuals w/o #SMuRFs (#T2D, #HTN, #smoking, #hypercholesterolemia) presenting w/ #AMI have⬆️risk of all‐cause #mortality with ⬇️ prescription rate for #GDMT👉 bit.ly/44oCWiZ #CVD #CVprev Zainali Chunawala Melissa Caughey PhD Dr. Deepak L. Bhatt John P Erwin III MD MBA FACC Arman Qamar MD MPH MIЯVΛƬ #IC

#cardiology #cardiotwitter #heartattack #prevention

Zainali Chunawala JAHA APS is much more common than people think and dramatically underdiagnosed. This is a perfect scenario to check IgG/M/A autoantibodies against beta-2 glycoprotein I, anticardiolipin, lupus anticoagulant. Up to 10% in acute MI. APS Foundation of America

Acute MI Patients Without Standard CVD Risk Factors at Higher Risk of Death tctmd.com/news/acute-mi-… Zainali Chunawala Melissa Caughey PhD John P Erwin III MD MBA FACC Dr. Deepak L. Bhatt Justin Levisay Mark J Ricciardi MD @NorthShoreWeb

1/ Debate: should we use CAC testing in familial hypercholesterolemia? Raul Santos vs. Don Lloyd-Jones #ASPC2023 Heterozygous FH is associated with high ASCVD risk Statin therapy changes natural history of FH But many pts persist with high LDL-C

1/ High-risk ethnicity: Focus on South Asians #ASPC2023 Anand Rohatgi South Asians have excess coronary disease risk Cardiometabolic risk ‼️ 🔗 ahajournals.org/doi/full/10.11…

Patients presenting with MI but without standard modifiable cardiovascular risk factors may have increased risk of all-cause mortality and lower ️use of guideline directed medical therapy. #AHAJournals Zainali Chunawala Melissa Caughey PhD Dr. Deepak L. Bhatt Arman Qamar MD MPH ahajrnls.org/3OxIxhK

Impressive showing by UTSW Internal Medicine residents highlighting their research at AHA! UTSW Internal Medicine Chiefs @DinoKazi Anish Bhatt James MacNamara Denis Wakeham Nicholas Hendren Sandeep Das

Among patients hospitalized w/ ADHF, those w/ concurrent PAD have more prevalent 🫀 comorbidities and higher likelihood of 1-y ADHF readmission, irrespective of CKD status 🔗atherosclerosis-journal.com/article/S0021-… Zainali Chunawala Dr. Deepak L. Bhatt Arman Qamar MD MPH Muthu Vaduganathan Robert Mentz, MD Justin L. Grodin Melissa Caughey PhD

Integrating a more holistic approach in management of 👫 w/ concomitant HF, PAD and CKD may be an important strategy to improve the prognosis in this vulnerable population 🔗atherosclerosis-journal.com/article/S0021-… Zainali Chunawala Dr. Deepak L. Bhatt Arman Qamar MD MPH Muthu Vaduganathan Robert Mentz, MD Justin L. Grodin Melissa Caughey PhD

Honored to be selected as a finalist for the Quest Diagnostics Early Career Investigator Award at #AHA2024! Deep gratitude to my mentors, ambarish and @KershawPatel, for their incredible mentorship and support. Excited to present at @AHAmeetings! @UTSWIMCHIEFS @UTSWHeart