Interested in #gdTcells in cancer? 👇🏼👇🏼👇🏼 we could write a grant together … it’s how I got my position with Karin de Visser and launched my career. Best decision I ever made

Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis nature.com/articles/s4155…

Thanks The Scientist for writing about our work on CAFs and EVs led by Alice Santi and Emily Kay!! And thanks Giulia Biffi for her comments!

New preprint from Giulia Biffi authored by Eloise Lloyd & colleagues: “SMAD4 and KRAS status shape malignant-stromal crosstalk in #PancreaticCancer” This work is a twofer because it dissects two important observations: (1) how the cooperating mutation with oncogenic KRAS

(3/7) Curious to dig deeper into the foundational background of my project? Check Ashwini's (our post-doc) manuscript to dig deeper into the iPDCs: biorxiv.org/content/10.110… & don't miss Tuula Salo & Sara Zanivan paper for more insights on the ome-gel matrix: sciencedirect.com/science/articl…

Many congratulations to Dr. Douglas Cartwright for successfully defending his PhD thesis on #CAFs in ovarian cancer CRUK Scotland Inst UofG Cancer Sciences A big thank you to Anniina Färkkilä for coming as external examiner! And to Fieke Froeling and Kendle Maslowski Lab for being internal examiner and convenor!

⏰Upcoming abstract submission deadline⏰ Make sure to submit your work to present at the BMSS-BSPR SuperMeeting in Warwick later this year!

Very excited to announce that we have launched a Science and Innovation at Cancer Research UK career development programme for #postdocs interested in transitioning to an independent cancer research group leader post!

Don't miss our next networking event, 'The challenges and benefits of becoming a team leader' 📅 20 June 🕓 13:00 CEST 🌍 Zoom ➡️ us02web.zoom.us/meeting/regist…

Is acetylation of proteins (and histones in particular) a cause or a consequence of gene transcription? We undertook an unbiased proteome-wide analysis of acetylation changes upon transcription inhibition and our results were just published nature.com/articles/s4146…

Extracellular vesicle–packaged PIAT from cancer-associated fibroblasts drives neural remodeling by mediating m5C modification in pancreatic cancer mouse models | Science Translational Medicine science.org/doi/10.1126/sc…

Fibroblast and myofibroblast activation in normal tissue repair and fibrosis nature.com/articles/s4158…

Neuro-mesenchymal interaction mediated by a β2 adrenergic-nerve growth factor feedforward loop promotes colorectal cancer progression. aacrjournals.org/cancerdiscover…

Excited to share the line-up of the Ovarian Cancer Research Syndicate speakers for the fall. Exciting topics from Rising Stars, early career investigators, and established faculty. Join us! Tullia Bruno, PhD Powell-Drescher Ovarian Cancer Research Foundation Daniel Powell Lab @ UPENN Katherine Aird Ben Bitler Emil Lou, MD, PhD, FACP Analisa DiFeo

Our new #paper is out in Nature Immunology. Applying #spatial transcriptomics at subcellular resolution to 130 ovarian #cancer tumors, followed by data-driven experimental design and high content #CRISPR screens to map immune evasion in ovarian cancer nature.com/articles/s4159… (1/15)

Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer: Cell Reports cell.com/cell-reports/f…

Classifying cancer-associated fibroblasts—The good, the bad, and the target: Cancer Cell cell.com/cancer-cell/fu…

Another interesting read from this week Cancer Cell! Fibrotic response to anti-CSF-1R therapy potentiates glioblastoma recurrence: cell.com/cancer-cell/fu…

📢 Hot off the press! CAFs are major regulators of the immune tumor microenvironment. In our new review we dissect a fascinating aspect of this regulation: CAF-induced physical constraints controlling T cell state and localization in solid tumours nature.com/articles/s4156…

We are looking for an enthusiastic and skilled Postdoc to study the roles of CAF metabolism in the immune-tumour microenvironment using cutting-edge spatial MS proteomics workflows and patient tissue samples. Start ASAP. crukscotlandinstitute.ac.uk/careers/postdo…