“In children, older patients and those receiving two or more concomitant hepatotoxic medications are at greater risk of flucloxacillin-induced hepatotoxicity”
doi.org/10.1093/jac/dk…
Amanda Gwee Laure Pittet OUP Medicine Oxford Journals #JACNews

BCG vaccine’s off-target effect on herpes simplex virus.

Results from the international 🇦🇺🇳🇱🇬🇧🇪🇸🇧🇷 #BRACEtrial published today show a beneficial effect of BCG on cold sore recurrence.

sciencedirect.com/science/articl…

#BCG #vaccine #RCT #HSV #IDTwitter #WeAreID eClinicalMedicine – The Lancet Discovery Science

🆕️⚡️⚡️ #JAC
Incidence and predisposing factors for flucloxacillin-related hepatotoxicity in children
Overall, the incidence of hepatotoxicity was 66/393 (17%) #IDXposts #Teamcefaz academic.oup.com/jac/article-ab…

Pre-XDR congenital tuberculosis in an extremely premature baby

✅ Just Accepted
🔓 Open Access
🔗 bit.ly/3EupBL1

via Alison Boast Josh Osowicki

#IDTwitter World Health Organization (WHO) recommends BDQ & DLM 💊 for MDR #TB at ANY age. We used both for an extreme prem 👶🏽 with congenital pre-XDR #TB . For #TB in kids, be reassured - you can use newer safer 💊. Alison Boast Justin Denholm Thx Clinical Infectious Diseases eds & reviewers 😊 doi.org/10.1093/cid/ci…

Great work Amy Legg ! (Sorry it's behind a paywall) Optimal drug therapy for Staphylococcus aureus bacteraemia... : Current Opinion in Critical Care journals.lww.com/co-criticalcar…

Our review explores potential reasons for the inconsistent findings between the 11 trials that have reported the effect of #BCG vaccination on protection against symptomatic #COVID19 .

bit.ly/44wYhq6
Christie Noble @immunity_lab Laure Pittet Clinical Infectious Diseases #BRACEtrial #IDtwitter

Incidence of GAS in 🇦🇺 👧👇

Increase in invasive group A streptococcal disease among Australian children coinciding with northern hemisphere surges
- important longitudinal data and collaborative effort authors.elsevier.com/sd/article/S26… Jane Oliver Murdoch Children's Research Institute (MCRI) NCIRS Josh Osowicki Christopher Blyth Joshua Francis

🆕️🔥Retrospective, multicenter, cohort study
Twice daily cephalexin is as effective as four times daily dosing for  for the treatment of uncomplicated UTI with a cefazolin-susceptible urine culture #IDXposts academic.oup.com/ofid/article/d…

Well done Yara Abo Josh Osowicki et al on this mammoth review!

Clinical spectrum of aspergillosis in patients with different immune status

(SAFS = severe asthma with fungal sensitization)

doi.org/10.1007/s11046…

Cefiderocol offers so much promise for treating MDR infections. We need to ensure it is prioritised for licensing in children to reduce the unnecessary burden caused by #AMR . bit.ly/43Rq97Y 🌍🏨🦠💊 #WHOPADO #GARDP

Number needed to investigate to identify 1 child presenting with IPD with an immunologic abnormality:
<2 y = 7 children
>2 y = 9 children

What is routine practice at your hospital?

#JournalClub by Shu Ki Tsoi Alison Boast Dr Natalie Yap (she/her) Nigel Curtis The Royal Children's Hospital, Melbourne reviewing Clinical Infectious Diseases paper on value of valaciclovir in reducing vertical transmission of CMV during early pregnancy bit.ly/44gGxQN ASIDANZ #IDTwitter #CMV #perinatalinfections #MedTwitter

academic.oup.com/ofid/article/d…
Don’t discount the impact of AKI, all AKI aren’t equal (more coming )! Mostly mild drug-induced AKI during the first 7/7 of CAMERA2. Swamped by the incredible mortality rate. Medial population survival estimate 3.4years. Joshua Davis Steven Tong

#IDtwitter & 🫁 docs, does your 🏥 routinely use molecular tests (beyond pneumococcal PCR) to test pleural fluid for CAP & pleural empyema? 🫁 🤒 🧪 🧬 In-house? Commercial (which)? Multiplex PCR? 16s/NGS? 🧪 🧬 Any insights? Antibiotic Steward Bassam Ghanem🆔🌟 Shivanthan Shanthikumar 🫁🫁 Catherine Satzke

Antibiotic myths busted

❌ cefaz 🚫 for CNS infxns
❌ LZD 🚫 with SSRIs
❌ LZD dose ⬇️ 🚫 in kidney dz
❌ Clinda 1st line surg ppx in “pen allergy”
❌ TMPSMX 🚫 vs GAS
❌ PO fosfo great for uUTI
❌ rif/gent needed for Staph PVE
❌ doxy 🚫 🤰👶🧒

academic.oup.com/cid/advance-ar…