Nuru Noor Shrinivas Bishu Zlatan Mujagic MD PhD Ashkan Rezazadeh MD Daniel Keszthelyi MD PhD Joost PH Drenth Lin Chang Kewin Siah John Damianos, M.D. Andrew Ong Johannah Ruddy M.Ed. (She/Her) ACG Greg Sayuk, MD, MPH Rome PsychoGastroenterology Baha Moshiree MD, MSci, FACG, AGAF Sarvee Moosavi MD, FRCPC Aline Charabaty, M.D. Vipul Jairath MD PhD Laurent Peyrin-Biroulet Silvio Danese Neeraj Narula Beatriz Gros Fernando Gomollón ignacio catalan We have been able to define stricter endpoints in UC that have really helped lower PBO rate, with the tradeoff that drug efficacy 'looks' lower.
This is harder in CD, as standard scopes don't always reach all of the affected bowel, but moving from CDAI to SES-CD has helped a lot.

Shrinivas Bishu Zlatan Mujagic MD PhD Ashkan Rezazadeh MD Daniel Keszthelyi MD PhD Joost PH Drenth Lin Chang Kewin Siah John Damianos, M.D. Andrew Ong Johannah Ruddy M.Ed. (She/Her) ACG Greg Sayuk, MD, MPH Rome PsychoGastroenterology Baha Moshiree MD, MSci, FACG, AGAF Sarvee Moosavi MD, FRCPC Aline Charabaty, M.D. Vipul Jairath MD PhD Laurent Peyrin-Biroulet Silvio Danese Neeraj Narula Beatriz Gros Fernando Gomollón ignacio catalan Strict criteria includes making the criteria more objective, and reducing the subjective judgement by the patient (wants to believe) and the clinician (also wants to believe, and may be influenced by revenue from enrolling patients in trials)

Early management of acute severe UC in the biologics era: development and international validation of a prognostic clinical index to predict steroid response gut.bmj.com/content/early/…

What can we do NOW in our endoscopy services ❓❓

Answer = A LOT in each step of patient journey 👇👇

Key principle = REDUCE &
RE-USE

Retrospective, observational cohort study in NHS Lothian

Inclusion: 163 CD patients on UST

Median follow up: 20.3 months

55/163 (=34%) underwent dose intensification
- to 4-weekly (n=50)
- to 6-weekly (n=5)

Finally published in Nature Communications

We show that intestinal epithelial cell specific clocks regulate circadian microbial rhythmicity and function, important for maintaining gastrointestinal homeostasis.

doi.org/10.1038/s41467…

Always such a pleasure to work with this amazing team.

Congrats Lauranne.

Happy to announce that the Issue 3 of ECCO News is out! 💥

A taste of ECCO23, grants, JCC podcast…

Thanks to everyone that contributed to this common effort 👍🏻

Check it out!!!

alessandro armuzzi Nuha A Yassin Spyros Siakavellas Brigida Barberio Y-ECCO my_UEG

ecco-ibd.eu/publications/e…

Confirmation bias is twisting the facts to fit your beliefs. Critical thinking is bending your beliefs to fit the facts.

Seeking the truth is not about validating the story in your head. It's about rigorously vetting and accepting the story that matches the reality in the world.

Abnormal bile acid metabolism contributes to irritable bowel syndrome, especially #IBS -D.

#MedTwitter #GITwitter #microbiome

jnmjournal.org/journal/view.h…

onlinelibrary.wiley.com/doi/10.1002/ue…

The #microbiome is an important mediator of nutrition’s impact on the gut-brain axis.

#MedTwitter #diet #nutrition #neuroscience #GITwitter

tandfonline.com/doi/full/10.10…

The therapeutic armamentarium for #IBD is further enriching. UEGJ my_UEG onlinelibrary.wiley.com/doi/10.1002/ue…

Silvio Danese Laurent Peyrin-Biroulet Y-ECCO Fernando Gomollón Gianluca Pellino Bram Verstockt Axel Dignass Raja Atreya

The ability of aromas to bring back highly specific memories is becoming better understood, and could be used to boost and heal our brains, according to a nature Outlook article. nature.com/articles/d4158…