Flying home from #DDW2024 full of positive energy and great ideas

Amazing people from across the world - clinicians, scientists, tech and industry- working together to improve patient outcomes.

Enjoying day 3 of #DDW2024

Missing the rest of the team but here we are representing the Edinburgh #IBD unit

Cannot explain how much I miss seeing these faces every day

Charlie Lees Nathan Constantine-Cooke Alex Elford

Digestive Disease Week #DDW2024

I’m going to start the field of omic-omics, studying the rate of things being called omics that should not be called omics. By 2030 every word in medical dictionaries will have an omic equivalent.

📢 On World #IBD Day weekend Carl Anderson and I are delighted to introduce Open-IBD!

£11M funding from Open Targets and Wellcome Sanger Institute

Open-IBD will study serial multi-omics and longterm outcomes from diagnosis in 1,000 people with IBD

More👇

opentargets.org/news/open-ibd-…

A few photos I took with the team on Thursday morning

Beatriz Gros Nathan Constantine-Cooke Nikolas Plevris

Individually we are a drop, together we are an ocean

Charlie Lees
Nathan Constantine-Cooke
Nikolas Plevris
Gareth-Rhys Jones
#Chiara #Lisa #Solomon
And missing people in the picture Lauranne Derikx #Alex

PhD available! We've genotyped thousands of patients with IBD and linked them to lifelong healthcare registry data. We want to go beyond susceptibility genetics and looking for a talented student to combine genomics, ML & epidemiology stillinger.aau.dk/phd-stillinger… #PhDjobs #PhDposition

JAK-STAT pathways can be complex to understand, gaining insight into their functions helps us comprehend the consequences of their blockade.

Bearing this in mind, I have done a summary attempting to synthesize this complexity focusing on #IBD therapies, I hope it proves useful.

Upadacitinib for Crohn's disease

• data from Edinburgh and Exeter
• n=93 with median 25w follow-up
• effective in highly refractory cohort

See 👇 for figures and link Frontline Gastro

I’ve been working with the British Society for Immunology (BSI) to develop a new online training course on IBD immunology in clinical practice.

The first gastroenterology day is on 5th June;
details 👉bit.ly/3x2jEEV
BSI Congress & Events JimBrewer Nikolas Plevris Beatriz Gros

Big congratulations to my friend Nikolas Plevris on successfully completing his doctoral thesis! 🎓👏

Your dedication and hard work have truly paid off

We are super proud of you 🤩🤩🤩

Although this is definitely not the case we HUGELY value the support from giants in the field of IBD like @ShromronH 👏🌎

One of the greatest things about ECCO is how much early career clinicians & researchers are supported👥👏

Ha, we love the idea of Geriatric-ECCO👵👴🧓

Once from Edinburgh always from Edinburgh

Charlie Lees ShahidaDin Eleanor Burt Claire O’Hare Jonny Blackwell Nikolas Plevris Nathan Constantine-Cooke Lauranne Derikx #Chiara

Edinburgh crew at ECCO

My picks of day 2 at ECCO

OP9: Ritecitinib and brepocitinib phase 2 umbrella study in Crohn's disease

OP10: Upadacitinib long-term extension data in Crohn's disease

OP11: Clinical utility of NUDT15 pharmacogenetics for thiopurines

OP12: Mirikizumab impact on fatigue, urgency

Fantastic presentation from James Lee who found a master regulator of gene expression in IBD inflammation in “the gene desert”. ETS2 signalling may be a key target for IBD therapies in the future.

#ECCO24

My top picks for day 1 at ECCO

OP1: PROFILE
- does the biomarker work?
- just how good is early biologic therapy in Crohn’s disease
- look out for the simultaneous publication today

OP2: IL23R-CAR-Tregs: creating a therapeutic breakthrough for Crohn’s Disease
- first data on

In Stockholm this week to enter the IBD galaxy! #ECCO24

We have secured Biotechnology and Biological Sciences Research funding for Edinburgh Data Science Training to deliver more workshops...
They're happening really soon and places fill quickly! Sign up here!
forms.office.com/e/zwE6byEtJR
1)  HD Statistics in R, Feb 27 - March 1
2)  HD Statistics in R, Mar 19 - 22
3)  ML in Python, Mar 26 - 29