The FOCIS Annual Meeting returns to San Francisco in just a few weeks! 🥳

🗓 Tuesday 18 – Friday 21 June

Check out the full programme & register now to discover the latest findings on immune-mediated diseases at #FOCIS2024 👉bit.ly/4cKMVUL

Review Series: Unconventional #Tcells in health & disease ✨

7 articles provide insight into these less-widely studied cells including #MAITcell interactions, #FOXP3 regulators, #ILCs & #Tregs in therapy

Guest edited by KMcNagny-Lab, Biomedical Miracles at work 👏

Free to read ➡️bit.ly/3JDOjvy

📸 Mediators of #Breg induction in the tumour microenvironment

Here, researchers at Barts and The London, Queen Mary discuss the heterogeneity of #Breg s, cellular interactions they make with other immune cells & the tumour, and how they enable tumour escape ➡bit.ly/3DAlhco

This review from UCL Rheumatology for Adolescents and Young Adults researchers summarises the key findings that have revealed the critical functions of #cytokines produced by human #Bcells in health & #autoimmune diseases ➡️bit.ly/3GHuiCO

📸 Timeline of cytokine-producing B cells discoveries

#Treg cell therapy has enormous potential for pathologies such as #autoimmune diseases & #TransplantRejection

Here, Oliver McCallion et al. Translational Research and Immunology Group review the current & future landscape covering adoptive transfers, CAR & 'off-the-shelf' 👉bit.ly/3PRIw8N

Memory #Bcell s that lack or express low levels of CD21 increase with older age & in chronic #inflammatory conditions

Here, Gjertsson et al. discuss CD21–/low #Bcell in different conditions, looking for similarities in gene signatures & functions ➡️bit.ly/3m6yYuT

On #WorldHAEDay , we're highlighting this updated UK consensus on prophylaxis in #HereditaryAngioedema 🩺

To establish an updated view of UK clinicians & patients, a Delphi process was used to develop statements on LTP & other aspects of #HAE management: bit.ly/3TNSHwc

#Eosinophils are fundamental in orchestrating the #allergic response & fighting pathogens 🛡️

Here, Pratibha Gaur et al. explore the direct and indirect interactions of eosinophils to sense viral, bacterial & fungal infections ➡bit.ly/3TIOWs1

Autophagy modulation in #MultipleSclerosis & experimental autoimmune encephalomyelitis

This review summarises the complex mechanisms of #autophagy in MS & #EAE , providing potential therapeutic approaches for the management of MS

Free access 👉bit.ly/49qrXYH

Extracellular vesicles containing #PDL1 contribute to CD8+ T-cell immune suppression & predict poor outcomes in small cell lung cancer

Dou et al. suggest that EVs containing PD-L1 can serve as a diagnostic biomarker for #SCLC therapy ➡️bit.ly/3PNYyk5

The FOCIS Annual Meeting returns to San Francisco on 18-21 June! 🎉

Check out the keynote speakers & register now to join renowned clinicians & researchers for the latest findings on immune-mediated diseases at #FOCIS2024 👉bit.ly/4cKMVUL

The #GutMicrobiome has recently been implicated in #autoimmune disorders (AID) via microbiome dysbiosis

In this review, University Hospitals Birmingham researchers explore evidence for the role of intestinal permeability, bacterial metabolism & molecular mimicry in AID 👉bit.ly/3U42BLt

#IL2 based approaches to #Treg enhancement

This review revisits the rationale behind using low-dose IL-2 as a therapy to treat #autoimmune diseases & evaluates outcomes of #ClinicalTrials to date

Read here 👉bit.ly/3qiXMBA

Explore new approaches to unleash #NKcells in #cancer immune surveillance & cancer #immunotherapy

In this review, Matthias Peipp et al. Universität Kiel CAU 🎓 introduce selected activating NK-cell receptors & their ligands 👉bit.ly/3J9b61L

This study on #bispecific molecules sheds light on their binding dynamics, showing that a balance in affinity for target versus CD3 is key for maximising T-cell activation while maintaining specificity ⚖️

#OpenAccess ➡️bit.ly/3TlNjRU

Must-read #immunology articles! 🤩

For #DayofImmunology , we invite you to explore this fantastic selection of our impactful articles, together with important research & reviews from our sibling journals Discovery Immunology Journal & Immunotherapy Advances Journal ➡️bit.ly/3DuBTCX

Do #Treg cells have a role in the pathomechanism of transient #hypogammaglobulinemia of infancy (THI)?

These findings from researchers at Uniwersytet Jagielloński Medical College expand our knowledge for the future diagnosis or management of THI: bit.ly/3JtRCoL #WorldPIWeek

#STAT3 variants can be loss or gain of function, causing very different diseases

This review from Joe Mackie et al. TangyeLab explores how studying #IEI has informed our knowledge of this #proinflammatory transcription factor 👉bit.ly/442dnoL

#WorldPIWeek

A deep-dive into one of #PrimaryImmunodeficiency 's best-characterised genes: #STAT1 🧬

Takaki Asano et al. discuss the pivotal roles of STAT1 in immune regulation as revealed by >150 mutations 👉bit.ly/3NhtAjI

Read more in our Review Series 🔗bit.ly/442dnoL

It's #WorldPIWeek ! ✨

Understanding more about #PrimaryImmunodeficiency will not only help us diagnose & treat these conditions but also further our understanding of the immune system

Take a look at this fantastic Review Series from our official journal Clinical & Experimental Immunology ⤵️