Seismic next three days for trauma research with the results of 3 big RCTs at criticalcarereviews.com Belfast. Free livestreams: Tomorrow 8am UTC: UK-REBOA UKREBOATrial ; 11am: PATCH (@PatchTrial) & most importantly (!) Friday 8am: CRYOSTAT-2 cryostat2

Anyone want to take a crack at predicting results of any of these? (I know the results so I can't play!!) Critical Care Reviews

The summer weather has hit us here in the East of England. However, despite the heat, our doctors and paramedics are still donning their protective uniforms and heavy boots, and travelling across the region to provide patients with lifesaving care when every second counts.

Are you going to be joining the CCR (Critical Care Reviews) meeting at 9am on the 16th June to hear about the cryostat2 results from Karim Brohi ?

Well done to Hants & IOW Air Amb for recruiting our 100th participant! Fabulous work! 👏 This much-sought after gift is on it's way to you! 🥰 @LGreenBartsNHS Ed Barnard Barts Charity Clinical Trials Unit Air Ambulances UK

#CRYOSTAT2trial #CCR23 cryostat2 primary outcome by timing of cryo non-sig difference in mortality per timing of delivery defining the optimum time point - worse outcomes if given early, and worse later...

#CRYOSTAT2trial #CCR23 cryostat2 primary outcome by subgroup penetrating trauma injury = worse outcome

Interesting discussion from cryostat2 results presentation. Trial primary result = no difference. Major trauma with bleeding is not one disease so looking for one treatment protocol may be an incorrect approach. We would not research to find a treatment that works for ‘cancer’.

Unexpected findings are my favourite sort of findings

CRYOSTAT2 results #ccr23: - Early *empiric* administration of high-dose cryoprecipitate to trauma patients activating the major haemorrhage protocol did not improve 28-day mortality. - possible evidence of harm if given very early or in penetrating trauma patients...

In the meantime some cryostat2 data from our #ccr23 presentation. Wait for the paper ofc, but I'd suggest: - If you're thinking about giving concentrated fibrinogen (in any form) up front to trauma patients, don't. - Prioritise getting fibrinogen (FIBTEM/FF) levels back asap

Karim Brohi cryostat2 🙏🙏🙏 amazing work. Look forward to reading the paper. Helpful to know that cryostat2 doesn’t disrupt motion that once hypoF IS identified that replacement is still beneficial! But love your point about not doing anything empirically to trauma pts! 🤣 seems to be true!

I did warn you this week would be seismic for trauma research & resuscitation! Papers need to be published & digested. Dust needs to settle. Things have changed. Huge thanks to Rob, Emma & the whole Critical Care Reviews team for an incredible meeting & for selecting CRYOSTAT2 🙏🏼.

A massive day for UK trauma with the publication in JAMA of two game-changing trauma trials: cryostat2 and UKREBOATrial. Both turning points in how we understand and treat trauma patients. UK-REBOA: jamanetwork.com/journals/jama/… CRYOSTAT-2: jamanetwork.com/journals/jama/…

With so much horror everywhere in the world, we must keep improving trauma care through research and global education. For us at CommsC4TS it's our path to try to make a difference, to try to make these events a fraction less terrible. Until humans stop hurting other humans.

Congratulations to all involved in this study, it’s a great achievement for all involved, including Nikki Curry Simon Stanworth, Ross, a truly excellent clinical trials team and of course Karim Brohi I’m proud to have chaired the steering committee for you.

Our UK-REBOA trial is out. A huge endeavour with major implications for UK trauma care-showing that use of #REBOA in the ED for exsanguinating haemorrhage did not reduce, and may increase mortality. Huge thanks to the entire trial team. Jan Jansen jamanetwork.com/journals/jama/…

Wonderful (and very generous) write up/run down of cryostat2 and its implications by the Saint Emlyn's team. stemlynsblog.org/cryostat-2-st-… 🙏🏼

Update for next week's national major trauma haemorrhage meeting: eventbrite.co.uk/e/uk-major-tra… Over 600 people signed up online or in person over the 2 days. We are FULL in person for Day 1, but you can still add to a waitlist if anyone drops out. Still places in person for D2 and

Thank you Clare Donegan, Senior Research Nurse ACET Research Team King's College NHS discussing research delivery in the ED. We can do better 😉 #Band6Developmentcourse King's College Hospital Research King’s EM Research Group Matt Edwards dr ahsen Ikram