Recap: This week in ACR journals

🔸 Minor Genetic Overlap Between RA and Myocardial Infarction
🔸 Transcriptomic Profiling of JIA and RA Synovia Reveals Significant Overlap
🔸 Anti-Infliximab Antibodies in Radiographic axSpA and Risk of Infliximab Tapering Failure

Accompanying editorial for this article: loom.ly/wm1v3AE

June A&R Editor's Pick

👉 Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Trial Completion

loom.ly/fFV20iM

June A&R Clinical Connections

🔹 CCL19+ Lymph Node Stromal Cells Govern Inflammatory Arthritis Onset via Trk

🔹 VEXAS-Defining UBA1 Somatic Variants in 245,368 Diverse Individuals in the NIH All Of Us Cohort

👉 loom.ly/PCKmuqU

June A&R In This Issue & Journal Club

- Antirheumatic Drug Choice and RA-LPD Prognosis
- Acute CPP Arthritis and Fracture Risk
- Guselkumab as Option for Psoriatic Arthritis
- LC-QTOF Mass Spectrometry for Investigating Environmental Chemicals in Blood

loom.ly/BIzSG54

This long-term cohort study demonstrated that the frequency and success of infliximab tapering strategy in radiographic axSpA was influenced by the presence of anti-infliximab antibodies

In A&R
loom.ly/Dvldixs

An RNA-seq study compared transcriptomic profiles of JIA and RA synovium

Findings showed significant similarities between JIA and RA synovitis. Similar to RA, JIA synovia could be broadly categorized into 2 groups based on transcriptomic signature

In A&R
loom.ly/uebEXLg

ALL-NEW EPISODE! NEW STUDY finds certain interventions have improved symptoms & fatigue for those with systemic sclerosis, particularly among those newly diagnosed. LISTEN HERE → acr.tw/3ZRheli ACR_Journals

⭐ Highlights from this week in ACR journals:

🔸 Osteoarthritis Impact in Younger Adults
🔸 Gout Flares With Start-Low Go-Slow Allopurinol Escalation
🔸 Antibodies to MAA Associated With RA-Interstitial Lung Disease
🔸 Biomarkers Associated With Deucravacitinib Response in PsA

What is the role of genetics in the elevated risk of cardiovascular disease among RA patients? This study used GWAS data from a Swedish RA cohort paired with data on myocardial infarction, illustrating minor genetic overlap between the traits.

In A&R
loom.ly/Un3PAaM

💜 Did you know CARRA has many researchers dedicated to childhood #lupus ?

🦋For #LupusAwarenessMonth , we want to highlight our newest Lupus Workgroup - the Neuropsychiatric Lupus Workgroup.

Check out their video ➡️ youtu.be/Z6uKEjnLmRo?si…
Lupus Association, Lupus Foundation of America, Lupus Research

This systematic review and meta-analysis found a dose-response effect between initial glucocorticoid dose and rates of complete response, serious infections, and death in patients with lupus nephritis

In A&R
loom.ly/ZLSbGj0
Gabriel Figueroa-Parra, MD, MSc Maria Carolina Cuellar Mariana Gonzalez-Treviño

In a cohort of US veterans with RA, protein-specific anti-MAA antibodies to collagen, fibrinogen, and vimentin were associated with prevalent RA-ILD, and IgA and IgM anti-MAA-albumin antibodies were associated with higher risk of incident RA-ILD.

In A&R
loom.ly/tY7jxVY

A phase 2 trial investigated the relationship b/w biomarkers and clinical responses to deucravacitinib for psoriatic arthritis
Results suggest deucravacitinib had better efficacy in patients with stronger activation of the IL-23 pathway at baseline

In A&R
loom.ly/m4DIOw4

Interpreting and Addressing Racialized Inequities in Rheumatic Disease Care and Outcomes:

Editorial on the below study is now online in AC&R at
loom.ly/LI6Kpq0

Radiomics uses ML to extract features from imaging.
An MRI-based joint space radiomic model developed using neural networks with meniscus & femorotibial cartilage radiomic features showed improved predictive values in radiographic knee OA incidence

In A&R
loom.ly/7WZGo6I

💙 Sharing this important reminder on #ClinicalTrialsDay . Thank you to physician-researchers like Yukiko Kimura and our patient families who are working together to advance #pedsrheum research!🎙️Check out our podcast➡️ tinyurl.com/5n73ura2
#clinicalresearch #clinicaltrials

Exciting research unveils shared metabolic signatures within entheses comparing psoriasis, psoriatic arthritis pts & healthy controls via cutting-edge MSOT imaging, underscoring a spectrum of psoriatic disease

In A&R
loom.ly/iRLm10Q
Koray Taşcılar @dr_david_simon Filippo Fagni

The published literature lacks studies that directly examine effects of climate change on rheumatic diseases. Collaborative translational and epidemiologic research is needed to enhance our understanding and awareness in this area.

ACR white paper in A&R
loom.ly/sBpVuqE

⭐ Highlights from this week in ACR journals:

🔸 Interstitial Lung Disease in ANCA+ vs ANCA- Patients
🔸 Upadacitinib in Active Non-radiographic axSpA
🔸 Scoping Review of Digital Programs for Lupus Self-Management Education
🔸 In Vivo Imaging of Entheses in Psoriasis and PsA