Let's not get too excited with this data - The study reported HDL (NMR) metrics, and not HDL functionality metrics. Neither HDL-P nor large HDL size are HDL functionality tests, so they really tell us nothing when evaluating INDIVIDUAL patients. If the presence of large HDL was

We need Dr. Spencer Nadolsky and Karl Nadolsky to chime in

This is a designation, i.e. potential important advance, but not approval yet. This assay is technically isoform dependent as it uses polyclonal antibodies. The only isoform independent assay available right now is the one we developed at UC San Diego Cardiology in 2022. We are working

This Roche assay breakthrough seems like potential progress for Lp(a) testing Roche granted FDA Breakthrough Device Designation for blood test measuring Lp(a) – a key marker for hereditary cardiovascular risk. What say the experts - Benoit Arsenault Marlys Koschinsky Sam Tsimikas, MD

Studies have not demonstrated an increased risk of cognitive impairment, Alzheimer's dementia, or hemorrhagic stroke associated with lowering LDL-C levels. The concerns about stroke and cognitive issues with very low LDL-C levels have been refuted. See LDL Cholesterol Lowering:

Amen to this advice. Many need to attend for this lecture alone. Do not wait for the CAC to be positive to start treating lipids, no more than one would wait for eGFR to drop before treating hypertension.

EAS encourages young scientists in atherosclerosis research for a thriving future. Funds are available for early-career projects. Apply by September 13, 2024: eas.to/Grants2024. Don't delay - act now! Prof Kausik Ray FMedSci

Now, if we only had a panel of HDL function tests to help us figure out whether HDLs are functional or dysfunctional. HDL-C has no relationship to these functions. National Lipid Association European Atherosclerosis Society

Here is the concluding paragraph in this elegant paper with which I wholeheartedly agree 'Recently published genetic research reveals that plant sterols are inherently atherogenic. As the German Society of Cardiology (DGK) recently stated, randomized controlled trials with

Is my cholesterol drug causing muscle aches? washingtonpost.com/wellness/2024/…

How about this study (in press) - EZETIMIBE as a player to prevent Alzheimer's Disease and Related Dementia (ARRD). See Aging Biology | Ezetimibe lowers risk of Alzheimer’s and Related Dementias over 7-fold, reducing aggregation in model systems by inhibiting 14-3-3G::hexokinase

MUST READ - New Term SMurfs - (1) IT IS CRIMINAL FOR CLINICIANS NOT TO TEST LP(a) IN ALL. We really need to take Lp(a) increases very seriously. - Way outside of the box, but I am at the point to advise Lp(a) patients to take a PCSK9i to blow away apoB and at least lower Lp(a)

THERAPEUTIC LIPIDOLOGY: Regarding treatment of patients who are cholesterol hyperabsorbers, diagnosed by having high phytosterol (e.g. sitosterol or campesterol) plasma concentrations, a non-prescription choice is Benecol. Under no circumstances should such patients be given

BIOMARKER HISTORY - During my Internal Medicine Residency (>50 years ago) in 1972-75 we had this state-of-the-art 12 test chemistry profile (called Sequential Multiple Analyzer-12 or SMA-12): note concentrations were not listed as mg/dL but rather mg%. There was no such thing as

Here is another teaching graphic from my file for Lipidaholics - Covering approximately 30% of the LDL surface, one apolipoprotein B100 (Apo B) molecule per particle constitutes the protein component of LDL particles (the most numerous member of the apoB family of lipoproteins:

Updated another of my older slides today - As usual lots of info packed into the graphic & as always it is more complicated than shown. National Lipid Association European Atherosclerosis Society International Atherosclerosis Society (IAS)

Understanding sterol lab reports - Unfortunately this is not often taught. The sterol profile shown below shows marked suppression of cholesterol synthesis (with below the limits of detection of lathosterol and desmosterol). First question to ask is patient on a statin? The