Federico Ferraris(@FFerraris_URO) 's Twitter Profileg
Federico Ferraris

@FFerraris_URO

Urologist.

ID:1280306808054255616

calendar_today07-07-2020 01:05:18

206 Tweets

640 Followers

566 Following

Zach Klaassen(@zklaassen_md) 's Twitter Profile Photo

PARPi + ARPI Combos for 1L mCRPC: A SR & MA Rashid K. Sayyid UroToday.com

PARPi/ARPI vs PBO/ARPI
📌3 trials
📌rPFS: HR 0.65, 95%CI 0.56-0.76
📌OS: HR 0.84, 95% CI: 0.72-0.98
📌Gr ≥3 TEAEs: RR 1.45
📌Gr ≥3 anemia: RR 6.22

#EAU24 PARPi + ARPI Combos for 1L mCRPC: A SR & MA @RKSayyid @urotoday PARPi/ARPI vs PBO/ARPI 📌3 trials 📌rPFS: HR 0.65, 95%CI 0.56-0.76 📌OS: HR 0.84, 95% CI: 0.72-0.98 📌Gr ≥3 TEAEs: RR 1.45 📌Gr ≥3 anemia: RR 6.22
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UroTeragLATAM(@UroTeragLATAM) 's Twitter Profile Photo

66 años, biopsia GLEASON 7 (3+4), PSA 584 ng/mL.

✅ estadificación inicial.
✅ PET-PSMA: compromiso local, no compromiso nodal, lesiones osteolíticas

Cual sería su manejo ?

Encuesta 👇

UroTarget Juan Pablo Sade FLoscoMD Mauricio Fernandez L Diego Barreiro Federico Ferraris Fabián YABER, MD PhD

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UroTeragLATAM(@UroTeragLATAM) 's Twitter Profile Photo

PET PSMA en la estadificación inicial: Más del 50% de los pacientes con metástasis óseas en centellograma / gammagrama óseo fueron negativos en PET PSMA.

Pacientes condenados a ADT y sus efectos adversos cuando eran localizados.

UroTarget Thomas Hope Michael Hofman

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Neeraj Agarwal, MD, FASCO(@neerajaiims) 's Twitter Profile Photo

Just in👉 Eur J Cancer EORTC : Analysis of ph3 TITAN trial patient-level data (n=1052)👉⬆️OS, time to CRPC with apalutamide regardless of disease volume/denovo mCSPC Doublet active in most Axel S. Merseburger Anders Bjartell t.ly/mHi5a OncoAlert UroToday.com

Just in👉 Eur J Cancer @EORTC : Analysis of ph3 TITAN trial patient-level data (n=1052)👉⬆️OS, time to CRPC with apalutamide regardless of disease volume/denovo mCSPC #prostatecancer Doublet active in most @amerseburger @bjartell t.ly/mHi5a @OncoAlert @urotoday
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Sabine D. Brookman-May(@brookmans76) 's Twitter Profile Photo

Great talk by Ploussard Guillaume Combination of systematic and targeted should still be the gold standard to detect clinically significant and allow better prognostic and treatment counseling also due to lower rates of Gleason Score upgrading from biopsy to RP

Great talk by @GPloussard Combination of systematic and targeted #biopsy should still be the gold standard to detect clinically significant #ProstateCancer and allow better prognostic and treatment counseling also due to lower rates of Gleason Score upgrading from biopsy to RP
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Matthias Guckenberger(@Mat_Guc) 's Twitter Profile Photo

CORE trial presented at about SOC vs SOC & SBRT in oligometastatic lung, breast or prostate cancer
Randomised signal finding study
👉 SBRT well tolerated
👉 HR 0.79 difference > 5mo 👍

CORE trial presented at #ESTRO23 about SOC vs SOC & SBRT in oligometastatic lung, breast or prostate cancer Randomised signal finding study 👉 SBRT well tolerated 👉 HR 0.79 difference > 5mo 👍
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Ashish M. Kamat, MD, MBBS(@UroDocAsh) 's Twitter Profile Photo

In well selected patients - solitary tumors < 7 cm, no or unilateral hydronephrosis, minimal CIS - results with TMT are comparable to Radical Cystectomy



thelancet.com/journals/lanon…

The Lancet Oncology Bladder Cancer Advocacy Network

In well selected patients - solitary tumors < 7 cm, no or unilateral hydronephrosis, minimal CIS - results with TMT are comparable to Radical Cystectomy #patientchoice #bladdercancer #BladderCancerMonth23 thelancet.com/journals/lanon… @TheLancetOncol @BladderCancerUS
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Sabine D. Brookman-May(@brookmans76) 's Twitter Profile Photo

Maha Hussain summarizing doublet/triplet treatment for based on . Which patients benefit most from triplet T suppression+NHT+docetaxel? Based on mainly synch HV. Interesting to see responses to questions asked

Maha Hussain summarizing doublet/triplet treatment for #mCSPC based on #TITAN #ENZAMET #ARASENS #PEACE1. Which patients benefit most from triplet T suppression+NHT+docetaxel? Based on #ENZAMET mainly synch HV. Interesting to see responses to questions asked #AUA2023
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Neeraj Agarwal, MD, FASCO(@neerajaiims) 's Twitter Profile Photo

Breaking news from Amer. Urol. Assn. : Sia Daneshmand, M.D. presents 1st results from SunRISE-1 trial 👉TAR-200 (local gemcitabine delivery system in bladder) in BCG refractory high-risk non-muscle invasive 👉 amazing ~73% complete response 👇OncoAlert UroToday.com

Breaking news from #AUA23 @AmerUrological : @siadaneshmand presents 1st results from SunRISE-1 trial 👉TAR-200 (local gemcitabine delivery system in bladder) in BCG refractory high-risk non-muscle invasive #bladdercancer 👉 amazing ~73% complete response 👇@OncoAlert @urotoday
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Zach Klaassen(@zklaassen_md) 's Twitter Profile Photo

First Analysis of Safety/Efficacy of UGN-101 for Ureteral Tumors UroToday.com

📌 136 renal units, 47 cases w/ ureteral tumors
📌 No difference (renal pelv vs ureter) in:
- 1st endo eval
- Recur Rate
- Prog Rate
📌 5.4% rate of new ureteral stenosis

First Analysis of Safety/Efficacy of UGN-101 for Ureteral Tumors @urotoday #AUA23 📌 136 renal units, 47 cases w/ ureteral tumors 📌 No difference (renal pelv vs ureter) in: - 1st endo eval - Recur Rate - Prog Rate 📌 5.4% rate of new ureteral stenosis
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Rashid K. Sayyid(@RKSayyid) 's Twitter Profile Photo

EMBARK: 3 arm enza/LHRH, LHRH only, enza only
BCR post-RP or XRT (PSADT≤9 mo), CT/bone scan: neg mets
1⃣ endpoint: MFS in enza/LHRH vs LHRH arm (HR:0.42, p<0.0001)
🔷OS favors combo (HR:0.59, p=0.014)
🔷All key 2⃣ endpoints in favor of combo
🔷No new safety sig
UroToday.com

EMBARK: 3 arm enza/LHRH, LHRH only, enza only BCR post-RP or XRT (PSADT≤9 mo), CT/bone scan: neg mets 1⃣ endpoint: MFS in enza/LHRH vs LHRH arm (HR:0.42, p<0.0001) 🔷OS favors combo (HR:0.59, p=0.014) 🔷All key 2⃣ endpoints in favor of combo 🔷No new safety sig @urotoday #AUA23
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Zach Klaassen(@zklaassen_md) 's Twitter Profile Photo

Rx Patterns of Systemic Rx for mCSPC (MP11) UroToday.com

**NHT Rx increased
- Chemo, first gen AA, & LHRH monoRx: unchanged or decreased since 2015

**Med Onc: more NHTs than urologists (45% vs 19%)

**Urologists: more LHRH monoRx than Med Onc (69% vs 38%)

Rx Patterns of Systemic Rx for mCSPC (MP11) @urotoday #AUA23 **NHT Rx increased - Chemo, first gen AA, & LHRH monoRx: unchanged or decreased since 2015 **Med Onc: more NHTs than urologists (45% vs 19%) **Urologists: more LHRH monoRx than Med Onc (69% vs 38%)
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