Is GLP1RA + SGLT2i the new “standard of care “ for initial therapy of T2DM with or without abnormal albuminuria? Not according to ADA/KDIGO. Cost effective compared to Metformin?

Just wondering- since the renoprotective benefits of SGLT2i are at least partially dependent on the magnitude of proteinuria ( with a possible upper threshold of 5gms/d) what is the evidence that they are usefully renoprotective in chronic tubulo-interstitial kidney disease?

Has anyone shown convincing efficacy and safety for the use of steroidal MRA (spironolactone or eplerenone) to slow progression of non-diabetic CKD (with or without proteinuria, when added to RASi and good BP control)?

Serum Cystatin C (and thereby eGFR-Cystatin C ) “predicts “ CVD better than Serum Creatinine (and thereby eGFR-Cr) mostly for non-GFR related reasons. eGFR -Cystatin C is no more accurate than eGFR- creatinine for “predicting “ measured GFR.

I am biased , of course, but the leading Nephrology non-society based Journal (American Journal of Nephrology) does a very good job with peer -review (timely, rigorous, fair, helpful). Thanks to Editor- in- Chief, Dr. George Bakris.

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What are the modifiable risk factors that been proven to be causal for incident CKD, other than Diabetes and Obesity? The answers to this question are crucial for public policy and individual behavior changes designed to reduce the burden of CKD through preventative measures

Good news from the USPSTF. After a decade they are going to revisit recommendations for population based screening for CKD. Kudos to the NKF, ASN and the C4KH for bringing this issue to the forefront. Now we can await the findings and recommendations of the USPSTF.

What is the nucleic acid content of nutritional yeast? Will regular consumption elevate the serum uric acid level?

Is the fraction of an infusion of Rituximab excreted in the urine greater in a patient with Nephrotic Syndrome due to Membranous Nephropathy than in a patient with a similar degree of Nephrotic Syndrome due to Minimal Change Disease?

Happy New Year !!! May this year be full of joy, peace and safety from the ravages of COVID.

X is linked to Y. Eating Z will make (insert organ) more “healthy”. What does all this obscuratory wordsmithing really mean?