Adaptive #autophagy regulation revealed 🚨: The molecular starting point for autophagy involves a complex interplay of proteins. Here, Angelina Gross Graef Lab demonstrate that the complex composition adapts to specific nutrient deficiencies. More in 🧵 nature.com/articles/s4155…

Ever wondered how cells adapt #autophagy to various forms of stress?⚡️ So happy to share our story on the plasticity of the Atg1 kinase complex in response to #phosphate starvation. For more details read here 🧵 and here nature.com/articles/s4155…

Here is our latest publication on how cells integrate metabolic information to elicit autophagy in response to phosphate starvation. Awesome work from Angelina Gross, Ruben, Max, Andrew, Elke, and Bethany with the help from DengjelLab! doi.org/10.1038/s41556…

Here is a really nice News & Views on our paper by Xiaoli Ma and Hong Zhang: nature.com/articles/s4155…

Exciting discoveries from Sho Suzuki (he/him) in the Emr lab — bringing it full circle back to the classic Emr lab vps screen: a mechanism for how intraluminal vesicles formation steals membrane from the limiting membrane yet the organelle doesn’t shrink — VPS13 supplies new lipids!

Congrats to Dr. Shanlin Rao Hummer Lab et al. for revealing in high detail the gymnastic of the LC3 lipidation machinery as it prepares autophagic membranes for cargo engagement using MD simulations, in vitro reconstitution and cell biology science.org/doi/10.1126/sc…

Molecular simulations, biochemistry, and cell biology come together to reveal how a crucial step in autophagy is executed. The work was made possible through a fantastic synergy between three labs, including ours, located in different continents across the world.

I am super excited to share that my first corresponding author paper has been published in JCB (JCellBiol). Surprising role of ER in ESCRT-mediated sorting! rupress.org/jcb/article/22… (1/8)

Dynamin-like proteins at the nuclear envelope? That and other surprises in excellent work by Philip Mannino with help from Nick Ader Melia Lab and LusKing Lab! #autophagy biorxiv.org/content/10.110…

The human prohibitin complex forms a bell-shaped structure in the inner mitochondrial membrane. Check out our #preprint together with Michael Ratz below 👇 biorxiv.org/content/10.110… What do you think it looks like? Like a bundt cake? A jellyfish? Vanilla pudding?😉

I am thrilled to see our work on the #Vacuole #LipidDroplet #MembraneContactSite vCLIP published in Developmental Cell! Fantastic collaboration with Ruben Fernandez and Oliver Schmidt. Huge thanks to the whole team, I am so proud of you all! sciencedirect.com/science/articl…

We are happy to share the publication below, which sheds light on the role of Atg1, Atg11 and Atg13 in bulk autophagy initiation. You can find the paper in the following link 👇 pubmed.ncbi.nlm.nih.gov/38233718/

🚨The Weill Institute is hiring a new faculty member!🚨 Assistant Professor position is now open in Weill Institute for Cell & Molecular Biology, joint with Cornell MBG. This is an open search in all areas of molecular and cell biology; application deadline is 3/20. More info: academicjobsonline.org/ajo/jobs/27253

Beautiful work from the Lackner Lab as always!

Excited to share the latest work from Lackner Lab led by jason casler with assistance from Clare Harper, Antoineen White, and Heidi Anderson. A tour de force that details roles for our favorite mitochondria-ER-PM contact site in mitochondrial division and PI4P distribution!

Eat less to live longer? #Autophagy degrades damaged or toxic cellular material to keep cells in good shape. We discovered how #ATG16L1 shapes phagophores. Our article was published today in NatureStructMolBiol ! thanks to all the authors !! Check it out: nature.com/articles/s4159…

Can also find the paper on open access at Cell cell.com/cell/fulltext/…

Huge congrats to Sadig Sadig Niftullayev who has successfully defended his doctoral thesis🥳✨🍻!!! #PhDone MPI for Biology of Ageing Cologne Graduate School of Ageing Research

🚀Excited to share our latest paper, where we explore dynamic changes in mtDNA heteroplasmy in living cells! Discover how asymmetric partitioning and mitochondrial dynamics drive mtDNA variant segregation! 🔬embopress.org/doi/full/10.10… #Mitochondria #microscopy #microfluidics #mtDNA

We’ve worked out how the molecular machines that create acidic compartments can recruit autophagy (self-eating) machinery when they can’t maintain a pH gradient. We are really pleased with this discovery, out in Molecular Cell cell.com/molecular-cell…. 1/16