Phospho-KNL-1 recognition by a TPR domain targets the BUB-1–BUB-3 complex to C. elegans kinetochores, say Jack Houston, Taekyung Kim, Arshad Desai (Arshad Desai) Oegema/Desai Labs UC San Diego and colleagues: hubs.la/Q02rZrQh0

#CellCycle #CellDivision #Genetics

Recombinant biosensors for multiplex and super-resolution imaging of phosphoinositides. New toolkit presented by Hannes Maib (Hannes Maib), Francesca Bottanelli, Petia Adarska, David Strutt and colleagues: hubs.la/Q02s6VXk0

#lipid #Biochemistry #Technology

The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic. A new study from Margaret S. Robinson and colleagues Cambridge University: hubs.la/Q02rZtzx0

#Trafficking #Organelles

A working model of LET-767's role in #lipid droplet (LD) protein targeting, from a study by Fu et al. which identifies LET-767 as a novel regulator to determine LD protein targeting and lipid homeostasis. hubs.la/Q02r8W4X0

#Metabolism #Organelles #Membrane #lipid

IRE1a recognizes a structural motif in cholera toxin to activate an unfolded protein response. New study from Mariska Simpson, Michael Grey, Wayne Lencer and colleagues Boston Children's: hubs.la/Q02rZdjy0

#ProteinHomeostasis #Biochemistry

My San Diego journey continues w a visit at UCSD 🥳 Meeting a few JCellBiol board members and some of the many excellent scientists here!

Video shows 3D invasion of a singles spheroid treated with CM from Lama3 WT leaders. From Sung Bo Yoon, Adam Marcus PhD et al. showing that subpopulation commensalism promotes Rac1-dependent invasion of single cells via laminin-332. hubs.la/Q02r9ywd0

#Migration #Cancer

An overview of pathogen effectors targeting plant #trafficking pathways and organelles. In this review, Deepak Bhandari & Brandizzi Lab discuss the current understanding of the post-immune activation logistics of plant defense. hubs.la/Q02r9qWZ0

#PlantBiology

ICYMI: we present a special magazine w/ some of the research articles from our Cancer Cell Biology collection (hubs.la/Q02rQpTG0), as well as cancer research published in other Rockefeller U. Press journals, JExpMed & LifeScienceAlliance. Download the PDF ▶️ hubs.la/Q02rQ3Sp0

Faa1 #membrane binding drives positive feedback in autophagosome biogenesis via fatty acid activation, say Verena Baumann, Sonja Achleitner, Susanna Tulli (susanna.tulli), Sascha Martens (@martens_sascha) and colleagues Max Perutz Labs Vienna: hubs.la/Q02rQB2d0

#autophagy

Discover novel cross-talk between TGFβ & HER2 signaling, as well as the mechanisms by which keratinocyte signaling is usurped by melanoma cells to aid their spread, in our new collection highlighting research advances on #cancer #cellbiology ➡️ hubs.la/Q02rzfwk0

#AACR2024

Image shows Ypt7 functions on mature endosomes. Füllbrunn, Langemeyer, Christian Ungermann and colleagues show that the GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes. hubs.la/Q02qX2yL0

#Biochemistry #Membrane #lipid #Trafficking

📢 Final day of the exhibit show at #AACR2024 ! Stop by the Rockefeller U. Press booth #4147 to chat about our journal, pick up a copy of our cancer research magazine, and collect one of our exclusive tote bags! We look forward to meeting you!

Model for DDX6 limiting of stress granules (SGs) and modulating PB–SG interactions. Ripin, Parker et al. HHMI NEWS CU Boulder 🦬 demonstrate that P-body components can influence stress granule composition and docking with P-bodies. hubs.la/Q02qX3hw0

#Biochemistry #RNAbiology

Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders. New review from Gui-Jing Xiong and Zu-Hang Sheng (Zu-Hang Sheng) NINDS: hubs.la/Q02rGQwY0

#Trafficking #Neuroscience

Phosphatidylserine externalization is a marker for PM damage. However, PS synthesis and trafficking are also important for PM repair, in part through prompting the assembly of Tspn4 rings to limit the size of the damage.

Krakowczyk, Bragoszewski Nencki Institute of Experimental Biology PAS et al. discovered the unique ways human cells handle mitochondrial protein transport failures. They reveal a mechanism, distinct from fungi, where human cells rely on mitochondrial factors to clear blockages. hubs.la/Q02qM9-m0

Reviewers: Did you know you can receive credit for your #PeerReview contributions? Rockefeller U. Press journals assist in posting verified reviewer credit to ORCID records and the Web of Science Reviewer Recognition Service. Giving credit where it’s due: hubs.la/Q02qyZZy0

See the #Cancer Biology collection from our sister journal LifeScienceAlliance! 🔽 #AACR2024

📢 #AACR2024 attendees: Stop by the Rockefeller U. Press booth #4147 in the Exhibit Hall to chat about our journal, pick up a copy of our cancer research magazine, and collect one of our exclusive tote bags. We look forward to seeing everyone!