Great idea for patients in need of them

Unfortunately, though safe, this trial of an antibody against vascular adhesion protein - 1 was not able to reduce liver enzymes for patients with primary sclerosing cholangitis

doi.org/10.1097/hc9.00…

Important trial alert

Nina Kimer with ANOTHER huge trial in #cirrhosis care

Post-discharge intervention (home visits, phone calls, education) did not improve readmissions, survival, or quality of life - but some bright spots in secondary outcomes

journals.lww.com/hepcomm/fullte…

Liver transplant is a form a gene therapy for some rare inherited conditions

Today in Hepatology Communications, we report on the promise of gene editing and cellular therapy for Hereditary Tyrosinemia in mice. The cells were injected into the spleen

journals.lww.com/hepcomm/fullte…
#livertwitter

By the way, this is the ICD-10 code we recommended in this delphi process from last year in Hepatology Communications
ncbi.nlm.nih.gov/pmc/articles/P…

📑 LPAR1 antagonist, EPGN2154, improves liver #fibrosis and enzymes in preclinical #NASH 🐭 🐁
#LiverTwitter #OpenAccess

journals.lww.com/hepcomm/fullte…

📑 An online 💻📱mind-body intervention ⬆ mental health and quality of life in #PBC 🧘 
 
⭐️Those who took part >3x per week also had ⬇ fatigue!
#LiverTwitter #OpenAccess

journals.lww.com/hepcomm/fullte…

📑 The #GAAD algorithm is an in vitro diagnostic combining PIVKA-II and AFP, age and sex at birth, that significantly ⬆️ #HCC detection irrespective of disease stage, etiology or 🌍 region❕
#LiverTwitter

journals.lww.com/hepcomm/fullte…

📑 Smartphone 📱 sensors can serve as markers for alcohol craving & mood⁉️

💥 This study establishes feasibility of sensors for monitoring & prediction in #ALD -AUD❕
#DigitalPhenotyping #OpenAccess #LiverTwitter

journals.lww.com/hepcomm/fullte…

We issued the first retraction in Hepatology Communications history last week

It is being processed by the publisher

But I thought I would share some thoughts

Hepatitis D

1. Terrible outcomes compared to hepatitis B alone
2. There are new and emerging treatments
3. You don’t know if your patient has it unless to you test
4. Testing is infrequent

Best study on the subject: journals.lww.com/hepcomm/fullte…

Binu John in Hepatology Communications

#HepatitisD

INSUFFICIENT #HDV testing in #HepB patients

In this 41658(+)HBsAg VA cohort only 10.7% were ever tested for #antiHDV

BadNews: HCV(+) & HIV(+) were even less likely to be tested

GoodNews: testing increased over time (graph)

Hepatology Communications
t.ly/_jURb

Now online! Dig deeper with AASLD's #MASLD / #MASH Collection featuring articles from HEPATOLOGY Journal Liver Transplantation Journal (LTxJournal) Hepatology Communications ClinicalLiverDisease. bit.ly/3vXYuaQ
#LiverTwitter

📑 Wide variation in pre-procedural blood product transfusion practices in #cirrhosis

🔴 Limited use of guidelines📃
🔴 Variability ⬆️ within and between specialty groups
🔴 High amounts of 🩸 products used in procedures
#LiverTwitter #OpenAccess

journals.lww.com/hepcomm/Fullte…

New paper alert! 📜🧑‍💻

Delighted to share this comprehensive in vivo and in silico analysis - by Boehringer Ingelheim colleagues incl. myself - of the MTARC1 gene and its role in Metabolic dysfunction-associated steatotic liver disease .

Paper Hepatology Communications: journals.lww.com/hepcomm/fullte…

I love this review on AFP

journals.lww.com/hepcomm/fullte…

And you will too

Ju Dong Yang #LiverTwitter

Hepatology consultation was associated with 📉 return to alcohol use and hazardous use at 26 weeks in an inpatient population of patients with AUD

➡️ 21% of patients had evidence of ALD

Bilal Khalid Bilal Asif, MD CKoh #theoheller Hepatology Communications

journals.lww.com/hepcomm/fullte…

📑 Altered profiles of circulating cytokines in chronic liver diseases (NAFLD/HCC): Impact of the PNPLA3I148M risk allele

journals.lww.com/hepcomm/fullte…

📑 Do pts w cirrhosis +/- MHE have longer reaction times (RT) in a newly developed virtual reality driving test⁉️

Prospective Study:
👉Pts w MHE had longer RTs compared to no MHE or controls
👉Longer RT asscoiated w ⬆️ car accidents/🛑 driving due to HE

journals.lww.com/hepcomm/fullte…

📑 Serum 25-hydroxyvitamin D, type 2 diabetes, and liver-related outcomes❗️

☀️Synergistic association of vitamin D deficiency and T2DM with liver-related outcomes
☀️Vitamin D deficiency associated with ⬆️ liver-related outcomes in individuals with T2DM

journals.lww.com/hepcomm/fullte…

📑 Mortality causes in patients with cirrhosis❓
 
In this study including, >200,000 patients from 2000-2017 , Peter Wang et al found:
 
⭐️ Compensated or #NAFLD  ➡️ 🫀disease and non-liver cancers 
⭐️ Decompensated or #ALD  ➡️ liver causes
#LiverX

journals.lww.com/hepcomm/fullte…