.Lila Neahring et al. Sophie Dumont UC San Francisco identify two spindle motors that promote twist in the mitotic spindle, but find that the spindle positioning machinery counteracts it, revealing that twist is set by factors within and outside the spindle. hubs.la/Q02BKW-b0

#Mitosis

#ESCRT disruption provides evidence against trans-synaptic signaling via extracellular vesicles, say Erica Dresselhaus (edresselhaus), Avital Rodal Rodal Lab Brandeis University and colleagues: hubs.la/Q02zRz-W0

#CellSignaling #Trafficking #Neuroscience #Drosophila

#AI application to super-resolution #microscopy accelerates discovery of novel biology in the absence of ground truth. hubs.la/Q02BzcwY0

UBC School of Biomedical Engineering Ivan Robert Nabi Ben Cardoen Guang Gao Ghassan Hamarneh Medical Image Analysis Lab @ SFU UBC Life Sciences Institute UBC Cellular & Physiological Sciences SFU Applied Sciences SFU School of Computing Science SFU Research

Perspective: Huna, Martin, Bernard et al. CRCL Centre Leon Berard provide insights into the shifting perception of cellular #senescence : from a mere cell proliferation arrest to a reinforcement or change of cell identity. hubs.la/Q02Bz1wp0

#Disease #Physiology #CellSignaling

In human cells, the S-phase-promoting kinase CDC7 exists in complex with either DBF4 or DRF1. Göder et al Centre for Chromosome Biology show that while CDC7’s essential function can be supported by both, DBF4 is the primary mediator of CDC7 activity during DNA replication hubs.la/Q02By-R20

The HERCulean task of recognizing, ubiquitinating, and shielding misfolded integral membrane proteins. Christopher Guerriero and
Jeffrey Brodsky University of Pittsburgh discuss new work from Kamada et al. (hubs.la/Q02zFgK50) in Spotlight: hubs.la/Q02zFHfb0
#ProteinHomeostasis

Profilin affects #microtubule dynamics via #actin . Heidi Ulrichs Heidi Ulrichs & Shashank Shekhar Shekhar lab highlight work by Bruno, Eric Vitriol et al. (hubs.la/Q02zsMGV0): hubs.la/Q02zsLHq0

#cytoskeleton

Excited to share St. Jude Research Lead Researcher Shariq Ansari new paper out TODAY JCellBiol 🥳

Great collaborative effort with SJ colleagues and Elaine Shelton VUMC Pediatrics!

A new study from Ansari et al. @Lab_Ogden St. Jude Research reveals signal crosstalk between Sonic Hedgehog and Prostaglandin signaling pathways that promotes primary cilium homeostasis for signaling competency. hubs.la/Q02B65xR0

#Development #Cilia #CellSignaling

Intraflagellar transport speed is sensitive to genetic and mechanical perturbations to flagellar beating, say Sophie Gray, Cecile Fort, & Richard Wheeler Nuffield Department of Medicine hubs.la/Q02zkQjf0
#cilia #flagella #Leishmania #microscopy

Image shows how IQGAP1 promotes the dynamic exchange of #actin filament end-binding proteins. Morgan Pimm, Henty-Ridilla et al. reveal a new role for IQGAP1 in promoting protein turnover on filament ends hubs.la/Q02ypjbF0

#Cytoskeleton #Biochemistry

Luxton G.W. Gant Luxton Lab 🏳️‍🌈🔬 UC Davis discusses new findings from the Roux group (hubs.la/Q02zYSKw0) that show how changes in cellular GTP levels alter the rates of nucleocytoplasmic transport. hubs.la/Q02zZ0gV0

The #mitochondria –ER–PM contact site mediated by Num1 regulates the distribution of PI(4)P and mitochondrial dynamics. From jason casler, Laura Lackner and colleagues Lackner Lab: hubs.la/Q02ykg240

#membrane #lipid #Organelles #Biochemistry #ER_literature

And now published JCellBiol! rupress.org/jcb/article-ab…

.edresselhaus et al. Rodal Lab Brandeis University show that ESCRT depletion disrupts synaptic extracellular vesicle (EV) release without affecting signaling by several EV cargoes. hubs.la/Q02zRzRC0

#CellSignaling #Trafficking #Neuroscience #Drosophila

Image shows that the SSH domain is essential for HP1 binding, inner centromere recruitment of HP1, and CPC function. Sako, Nishimura, Hirota et al. show that a bipartite binding interface recruits HP1 to chromosomal passenger complex at inner #centromeres . hubs.la/Q02yhFnm0

Model of the regulation of autophagosome biogenesis by AMPK. Carlo Barnaba, David Broadbent, Jens Schmidt et al. clarify AMPKs regulatory role in #autophagy and highlight its potential as a therapeutic target to reduce autophagy. hubs.la/Q02y6LsL0

#CellMetabolism #Cancer

Spotlight: Guerriero and Brodsky University of Pittsburgh discuss new results from Kamada et al. (hubs.la/Q02zFBlG0) showing the ER-associated degradation of misfolded CFTR by the E3 ligase HERC3. hubs.la/Q02zFB4L0
#ER_literature #ProteinHomeostasis

📢New publication in Journal of Cell Biology!

Our spotlight 'Profilin affects microtubule dynamics via actin' just out in JCellBiol

Written with my amazing student Heidi Ulrichs!

Emory University Emory College
bit.ly/4aI0YIE

.Heidi Ulrichs & Shekhar lab highlight work by Bruno,
Eric Vitriol et al (hubs.la/Q02zsLrs0), showing that #microtubule number & stability increases after prolonged depletion of profilin 1 or F- #actin due to loss of actomyosin contractility: hubs.la/Q02zsLgd0