🔬 New research in @JORSpine evaluates expulsion testing protocols for NP replacement devices. Discover how varying protocols impact their performance, providing key insights into device stability and safety.

Full paper here 🔗doi.org/10.1002/jsp2.1…
ORS Spine Section

Expulsion has been a common problem with nucleus replacement devices. In this JOR Spine paper we compare in vitro test methods to assess expulsion risk to help improve future pre-clinical assessments: dx.doi.org/10.1002/jsp2.1…

New @JORSpine study by Devina Purmessur (Walter) et al explores the role mast cells/macrophages in 🐩-IVD degeneration.

Read the full study here: 🔗doi.org/10.1002/jsp2.1…

New work published in JOR Spine presents a preclinical ovine model for congenital spine and chest wall deformities utilizing an in utero technique. This research aims to determine the impact of these deformities on lung development. #ORSSMC
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Exciting advancements in spinal #tuberculosis (TB) research!

Latest @JORSpine paper explores S100-A8 protein as a potential diagnostic marker for spinal TB and delves into its role in the disease's pathogenesis. 🦠

The full study here: doi.org/10.1002/jsp2.1…

New @JORSpine study explores the potential of #Apigetrin (API) on IVD degeneration. In vitro, API shows anti-inflammatory effects on NP cells. Rat models show it mitigates of degeneration. Thus API emerges as a promising treatment target.

Read all here: doi.org/10.1002/jsp2.1…

New work in @JORSpine shows a deep learning tool to automatically assess disc degeneration in dog spines using MRI scans, with high accuracy.🐩

Potential for clinical use and regenerative therapy studies in our canine patients.🐕

See it all here: doi.org/10.1002/jsp2.1…

From fusion length to implant types. Results underscore the need for consensus and deeper biomechanical understanding in AIS management.

Find all the details here: doi.org/10.1002/jsp2.1…

ORS Spine Section ISSLS

Exciting new findings by Stefan Dudli in disc microbiome research! 🦠

The latest work in @JORSPine delves into the microbiome of non-Modic, MC1, and MC2 discs, shedding light on dysbiosis patterns and bioinformatic nuances.

Find all details here: doi.org/10.1002/jsp2.1…

Cai & colleagues recently discovered that genetic variants associated with atherosclerosis are also associated with an increased risk of intervertebral disc disease (IDD).

May interventions targeting atherosclerosis reduce IDD?

Link: doi.org/10.1002/jsp2.1…

#ORSSMC JOR Spine

What is the role of complement system dysregulation in the pathogenesis of disc degeneration and Modic Change? Check out the proposed disease model from Irina Heggli, Stefan Dudli, James Iatridis, & OrthoLabUlm in JOR Spine : bit.ly/3xklilf.

#ORSSMC

Maho Koga & coauthors created an FEM of the cervical spine to simulate loading of intervertebral disc implants & analyzed the effect of cage placement and joint angle on stress, strain distribution, & migration. Read in JOR Spine: pubmed.ncbi.nlm.nih.gov/38156058/ #ORSSMC Bonassar Lab

Interested in injectable therapies for the #IntervertebralDisc ? Check out this study from Christopher Panebianco James Iatridis @mountsinaiortho
AO Foundation et al. evaluating in vivo performance of injectable #Biomaterial to slow #IVD degeneration: pubmed.ncbi.nlm.nih.gov/38156055/ #ORSSMC JOR Spine

Are you interested in intervertebral disc research? Now published in JOR Spine: the improvement of anterior intervertebral disc approach model in mice that will enable investigation of underlying mechanisms & potential therapeutic strategies. #ORSSMC
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🔬 New Research in JOR Spine!

Investigation on link between disc degeneration, Modic change, and chronic #LBP :
Blood levels of inflammatory markers in 240 participants sheds light on their potential associations.

Check out the findings: doi.org/10.1002/jsp2.1…

The findings from this study published in JOR Spine introduce a framework for using additive manufacturing to create a tunable, customizable biomimetic model of a cervical vertebral body. Check it out! #ORSSMC
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Learn about links among MRI features in paraspinal muscles, inflammatory processes, and related back pain in patients with lumbar disc herniation in this recent JOR Spine paper by Xiaolong Chen & coauthors: ncbi.nlm.nih.gov/pmc/articles/P… #orthoImaging #ORSSMC

📢 New work @JORSpine presents a pilot #clinicaltrial on the safety and efficacy of #PRP administration to IVDs in patients with #Modic type 1 change experiencing #backpain .

Read more for its impact on LBP management:
doi.org/10.1002/jsp2.1…

ORS Spine Section ISSLS

📢Latest publication in @JORSpine introduces a classification system for lumbar IDD using routine MRI images, offering reliability, reproducibility, and discriminative power compared to Pfirrmann classification.

Read: doi.org/10.1002/jsp2.1…

ORS Spine Section ISSLS

Generating AF-like cells from iPSCs! Learn more about guiding human induced pluripotent stem cells toward an annulus fibrosus-like fate for cellular delivery strategies in the recent publication in JOR Spine! @maucklab Ana P. Peredo, PhD
#ORSSMC
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