Nephrology Journal Club a 40% reduction (stat significant) in AKI3 a 30% reduction in RRT is there something else with these numbers in AKI prevention?

So would you start using amino acid infusions in your practice to PROTECT patients from AKI on the basis of this study? #NephJC

Nephrology Journal Club NEJM Anjana Gopal, MBBS, MD, DM Nephrology, FASN Samantha Verdugo the mechanism of action of amino acids renal protection have been described in details in this open acess signa vitae article by Rosario Losiggio, MDs Martina Baiardo Redaelli Rinaldo Bellomo Giovanni Landoni, MD San Raffaele Anesthesia and Intensive Care signavitae.com/articles/10.22…

• Significant inverse relationship between urine output and #AKIRisk Score. • AKIRisk Score thresholds may require adjustment for urine output. • Early serum creatinine may be superior to AKIRisk Score in predicting subsequent #AKI development. jcvaonline.com/article/S1053-…

Mark Ramzy, DO, EMT-P Clelia REBEL EM Salim R. Rezaie, MD Anand Swaminathan MD MPH 🏳️‍🌈🇺🇦 Journal of Cardiac Surgery Pitt Cardiothoracic Surgery Department Weill Cornell Medicine Cardiothoracic Surgery Stanford Cardiothoracic Surgery Columbia Cardiothoracic Surgery Eastern Cardiothoracic Surgical Society Johns Hopkins Cardiothoracic Surgery Marco E. Propersi, DO Ken Milne MD Rutgers Health Community Medical Center thanks for summarizing our NEJM #PROTECTIONtrial ! Rosario Losiggio, MDs Alessandro Belletti Martina Baiardo Redaelli Rinaldo Bellomo Giovanni Landoni, MD 小谷 祐樹 | Yuki KOTANI Gianluca Paternoster

Mark Ramzy, DO, EMT-P Clelia REBEL EM Salim R. Rezaie, MD San Raffaele Anesthesia and Intensive Care Anand Swaminathan MD MPH 🏳️‍🌈🇺🇦 Journal of Cardiac Surgery Pitt Cardiothoracic Surgery Department Weill Cornell Medicine Cardiothoracic Surgery Stanford Cardiothoracic Surgery Columbia Cardiothoracic Surgery Eastern Cardiothoracic Surgical Society Johns Hopkins Cardiothoracic Surgery Marco E. Propersi, DO Ken Milne MD Rutgers Health Community Medical Center In our NEJM #PROTECTIONtrial we found a 40% reduction in AKI3 for a vasodilator (intravenous amino acids) which costs few dozen euro for a 30h treatment this is likely to become standard of care in #cardiacsurgery with CPB and to be further investigated in several other

Mark Ramzy, DO, EMT-P Clelia REBEL EM Salim R. Rezaie, MD San Raffaele Anesthesia and Intensive Care Anand Swaminathan MD MPH 🏳️‍🌈🇺🇦 Journal of Cardiac Surgery Pitt Cardiothoracic Surgery Department Weill Cornell Medicine Cardiothoracic Surgery Stanford Cardiothoracic Surgery Columbia Cardiothoracic Surgery Eastern Cardiothoracic Surgical Society Johns Hopkins Cardiothoracic Surgery Marco E. Propersi, DO Ken Milne MD Rutgers Health Community Medical Center the mechanism of action of amino acids for renal protection have recently been described in details in this open acess signa vitae article by Rosario Losiggio, MDs Martina Baiardo Redaelli Rinaldo Bellomo Giovanni Landoni, MD San Raffaele Anesthesia and Intensive Care signavitae.com/articles/10.22

🆕A meta-analysis of RCTs of corticosteroids in children and young adults undergoing cardiac surgery 📰Pooled data from 17 RCTs totaling 6598 patients 💉Use of corticosteroids was associated with reduced mortality 🫀was also associated with lower VIS 🔓authors.elsevier.com/c/1jbc33lSIPxz…

#corticosteroids in #cardiacsurgery? There was debate for decades We probably found the answer: corticosteroids improve survival in patients <65y Free link the pooled randomized evidence for 40 days authors.elsevier.com/a/1jbc33lSIPxz… by Rosario Losiggio, MDs in Journal of Cardiothoracic and Vascular Anesthesia

In the September issue of Critical Care Medicine, our meta-analysis ‘Low Versus High Blood Pressure Targets in Critically Ill and Surgical Patients' A new perspective on blood pressure targets in critically ill patients. journals.lww.com/ccmjournal/ful… Giovanni Landoni, MD Ashish K. Khanna, MD,MS,FCCP,FCCM,FASA

The use of angiotensin II for the management of distributive shock: expert consensus statements Giovanni Landoni, MD CCR Journal Watch criticalcarereviews.com/latest-evidenc… Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at criticalcarereviews.com/newsletters/su…

An example of why it is important (mandatory) to report mortality data of RCTs according to the INTENTION TO TREAT principle the authors of this RCT (100 vs 100 patients) "exclude" up to 23vs10 pts with early death from the analyses thereafter they claim a 28-day-mortality

The #PixelWatch3, recently launched by Google, introduces an #AI loss of pulse detection feature, providing automated #CardiacArrest detection for the first time. Early recognition of cardiac arrest and calling for help are the first and most critical actions, yet they are

You’re dispatched to a patient with OHCA detected by their smartwatch. No one witnessed the event except the smartwatch, which automatically activated EMS. You have a cardiac arrest registry to complete. What do you flag? Witnessed or unwitnessed event? Let’s discuss and vote

Original Article: A Randomized Trial of Intravenous Amino Acids for Kidney Protection (PROTECTION) nej.md/45zYDyF Editorial: Amino Acid Infusion to Protect Kidney Function after Cardiac Surgery nej.md/3WKT3Fi #CriticalCare

Our #PROTECTIONtrial, which demonstrated that amino acids infusion reduces the occurrence of AKI in adults undergoing cardiac surgery, has been published in today’s issue of NEJM. Article: nej.md/45zYDyF Editorial: nej.md/3WKT3Fi Video: nejm.org/do/10.1056/NEJ…

on Thursdays fantastic colleagues worldwide read and extensively discuss the NEJM articles and they have no idea that everything already happened weeks before on X (Twitter)

Acute kidney injury is a common complication of cardiac surgery. Infusion of amino acids may exert protective effects in the kidneys. Research findings are summarized in a new Quick Take video. youtu.be/uhasD8BR_gE

10y ago our group was the first to suggest that Non-Adrenergic Vasopressors are likely life-saving in patients with or at risk for vasodilatory shock the topic is still hot pubmed.ncbi.nlm.nih.gov/26558621/ Alessandro Belletti San Raffaele Anesthesia and Intensive Care Fabrizio Monaco, MD

Raffaele Di Giacomo, PhD Society of Critical Care Anesthesiologists NEJM yes! mechanisms are described in detail here signavitae.com/articles/10.22… Rosario Losiggio, MDs Martina Baiardo Redaelli