I'll save the full tweetorial for Alex Lalejini and/or Luis Zaman but this is a really fun paper! Definitely check it out if you're interested in either of the following:

1. Steering evolution
2. Cross-talk between evolutionary computation and evolutionary biology

There is *much* more in the paper, so please check it out if you're interested in learning more or implementing some of these approaches in your own work.

I'm hopeful that the cross-talk between directed evolution and evolutionary computation will continue!!

13/end

And even when the objectives targeted by directed evolution are aligned with individual fitness (i.e., natural selection is efficient), these algorithms still provide large benefits for the metapopulation and the phenotypic spread of evolved populations!

12/n

They also produce the most diverse sets of phenotypes within subpopulations, and the most 'spread' through the space of possible phenotypes. This could be extremely valuable when trying to evolve novel therapeutics, for example!!

11/n

But long story short, LEX and NDE outperform the more standard algorithms even when evaluations are done for at the subpopulation level. And they work quickly, outperforming others after only 10 rounds of selection!

10/n

Lexicase (LEX) and Non-Dominating Elite (NDE) selection use the multidimensionality of evaluation to their advantage in different ways. Some of the details are in the paper, and some I'd claim are still under active research!

9/n

Tournament selection is intuitive, you pick some individuals/populations at random, and the best one is propagated. Now, the more advanced algorithms don't aggregate the different facets of performance into a single fitness value, and make explicit use of this dimensionality

8/n

With the lab up and running, I'm looking for Ph.D. & Master's students for '23, and a postdoc or postbac to start anytime. Find more info on my website! 3/3

Has anyone seen good attempts at efficacy data on simple box fan air filters in classrooms?

It's wild how many of these tv shows about the rise of fascism hit different in 2022

It's also the first definition of microbial evolution that appears on the nature portfolio website... hmm nature.com/subjects/bacte…

🥲

I can’t say enough great things about CABmicrobe! Amazing science and fun people. Super excited to get started on new collaborations.

Thank you María RG, Alejandra Rodriguez, Ana E. Escalante, Eria Rebollar and all the others that made this happen.