Very proud of our latest publication on a great collaboration with Kang Shen's lab in Stanford:
Endocytosis in the axon initial segment maintains neuronal polarity disq.us/t/4a08nb5

1/ Interested on protein degradation? Check out ProteasomeID, our new method to monitor proteasome interactions and substrates in cells and mouse models. 🧵👇 biorxiv.org/cgi/content/sh…

Fantastic Nature Chemical Biology cover art highlighting flavins for photocatalytic-based proximity labeling within intercellular environments that was wonderfully done by Yi Zheng.

More exciting efforts coming up in this space!

nature.com/nchembio/volum…

Want to make some ORANGE CAKE? My first publication with Harold MacGillavry, Arthur de Jong and Jelmer Willems is fully online! Duplex Labeling and Manipulation of Neuronal Proteins Using Sequential CRISPR/Cas9 Gene Editing tinyurl.com/2czz9y59. Here are the key messages🧵

Seminal #ubiquitin paper from #40yearsEMBOJ :
Cecile Pickart and colleagues defined tetra-ubiquitin chains as minimum requirement for proteasomal recognition
doi.org/10.1093/emboj/…
embopress.org/page/journal/1…

Do ya wanna sharpen up on how #superresolution is changing #neuroscience ? Then check out our new review published today in Trends Cell Biology
'Getting sharper: the brain under the spotlight of super-resolution microscopy'
sciencedirect.com/science/articl…
CNRS Aquitaine Bordeaux Neurocampus

I am pleased to share with you my review about cell types, published in Cell yesterday. 1/

What is a cell type and how to define it? cell.com/cell/fulltext/…

Expansion microscopy + STORM of cilia distal appendages 😮 biorxiv.org/content/10.110…

So great to see our study in Nature Communications highlighted in Spectrum (Autism Research News) magazine! Could Fragile X be a ribosome disorder? spectrumnews.org/news/plethora-…

Endogenous tagging for structural biology pnas.org/doi/10.1073/pn…

Check out our new paper for site-specific labeling proteins and building defined Ub/Ubl-protein conjugates using a plant Asp-endopeptidase.
Great effort by Max Fottner Johannes Heimgärtner Maximilian Gantz RaMue and TimonNK! Congratulations to all!👩‍🔬👨‍🔬🤩🙌🥳

Thrilled to share a new paper from the Howard Chang lab in Nature Biotechnology, co-led with Robert Chen! We systematically engineer circular RNAs for stronger translation, boosting yields >200-fold and enabling potent and durable protein production in vivo 1/

nature.com/articles/s4158…

Mitochondrial heterogeneity and homeostasis through the lens of a neuron | Nature Metabolism nature.com/articles/s4225…

Great summary of our Deep Visual Proteomics #DVP paper in the research highlight in Nature Methods by Rita Strack ´ #spatial #proteomics with subcellular resolution´. go.nature.com/3apgsZ5 #MassSpectrometry  CPRatUCPH Max Planck Institute of Biochemistry (MPIB) UCPH Healthscience Peter Horvath

Check out our preprint on speeding up conventional PAINT using switchable probes: biorxiv.org/content/10.110…
Brilliant collaboration with GeordieChemist Ezra Bruggeman Markus Körbel James McColl Kevin O'Holleran KlenermanLab Davis Lab Oxford Steven F. Lee

After PROTACs, here come DUBTACs:
nature.com/articles/s4158…

Treffpunkt #Lindau : Nach pandemiebedingter Pause konnte die Nobelpreisträger-Tagung dieses Jahr wieder vor Ort stattfinden. Mit dabei fünf Nobelpreisträger der Max-Planck-Gesellschaft und 22 Nachwuchsforscher*innen aus Max-Planck-Instituten bit.ly/3ybl10N Lindau Nobel Laureate Meetings

Paper out today Science Magazine! We used transcriptome imaging to profile 4000 genes in human cortex and revealed substantial increase in glia-neuron interactions in human over mouse, suggesting the evolution of glia cells may follow a more complexed spatial pattern!