1/4 Excited to share our latest preprint where we used observational and Mendelian randomization methods to explore the role of metabolites as intermediates between adiposity and endometrial cancer using data from UK Biobank (UK Biobank). medrxiv.org/content/10.110…

📢 Think body shape not (just) #BMI
#obesity subtypes & #ColorectalCancer just out in Science Advances
👏 Laia Peruchet Noray Anja Sedlmeier
Robert Carreras-Torres et al.
IARC #NCMTeam
🙏 Institut national du cancer
science.org/doi/10.1126/sc…

The accompanying Editorial: Identifying Genetic Loci Associated with an Increased Risk for Early Onset Colorectal Cancer
annalsofoncology.org/article/S0923-…

Important new study from IARC which 'provides new insights into people’s genetic susceptibility to early-onset bowel cancer, as well as strengthening our knowledge of the modifiable risk factors involved, notably body weight and alcohol intake.'
wcrf.org/latest/news-an…

#OpenAccess in Annals of Oncology, investigators report on genome-wide association & Mendelian randomization analyses to identify causes EOCRC. 2 novel risk loci are proposed & evidence is found on the impact of modifiable lifestyle & metabolic targets
annalsofoncology.org/article/S0923-… 2/2

The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally and the European cancer mortality predictions for the year 2024 published in the March 2024 issue of Annals of Oncology showed unfavorable trends annalsofoncology.org/article/S0923-…
1/2

1/9
🆕📰
Association between pre-diagnostic circulating #lipid #metabolites and #ColorectalCancer #risk

New publication from NIHR Imperial BRC Surgery and Cancer Research Fellow Rhea Harewood & IARC et al colleagues

Study funded by WCRF International European Commission

doi.org/10.1016/j.ebio…

IARC scientists &partners reveal🆕findings about genetic & lifestyle risk factors of early-onset #ColorectalCancer
Results may improve primary prevention, help prioritize screening
📰:Annals of Oncology
WCRF UK WCRF International Institut national du cancer Cancer Research UK Science and Innovation at Cancer Research UK
iarc.who.int/news-events/ge…

So pleased to see this important paper from Ruhina Laskar (now Early Cancer Institute, University of Cambridge), Neil Murphy (@IARCWHO) and CORECT/GECCO consortia -

GWAS & MR analyses provide insights into the causes of early-onset colorectal cancer

annalsofoncology.org/article/S0923-…

w/ explainer from Fred Hutch ↓

A new study co-led by Fred Hutch's Riki Peters provides insights into what's driving #colorectalcancer in people who are often too young to qualify for preventive screening. Alcohol consumption and obesity are two important, but modifiable, risk factors. bit.ly/4c1HD72

Genome-wide association study and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer

💥The incidence of early-onset CRC is increasing worldwide.
A comprehensive investigation into the aetiology of this👇

annalsofoncology.org/article/S0923-…

🔔🚨
Early onset colorectal cancer (EOCRC)
2 recent studies Annals of Oncology and JCO Oncology Practice

✅1️⃣Genome-wide association study and Mendelian randomization analyses

➡️6,176 EOCRC cases and 65,829 controls
➡️two novel risk loci for EOCRC at 1p34.1 and 4p15.33
➡️a deleterious…

important new insights re #eoCRC

#HCP - Take the time during #ColorectalCancerAwarenessMonth to learn more about #eoCRC

#HereditaryGICancer

A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator medrxiv.org/cgi/content/sh… #medRxiv

Incredible scenes from Tipperary today

Brilliant seminar by Richard Peto Harvard T.H. Chan School of Public Health about the influence of residual confounding in observational epidemiological studies. Compelling actual and hypothetical examples immediately suggest sensitivity analyses explicitly for this should be /cont youtube.com/watch?v=B0Zpen…

Ultra-processed foods (UPFs) are apparently the new poison, and a recent The BMJ report by Rebecca Coombes suggests conflicts of interests in the “expert” views presented @smc_london that weren’t enthusiastic enough in promoting this notion. bmj.com/content/383/bm… /cont

1/10: New commentary published in Obesity this week discussing the challenges and serious biases of nonlinear Mendelian randomization (MR) methodologies: onlinelibrary.wiley.com/doi/10.1002/ob…

Come and join our Team. My time at IARC is soon coming to an end but was fortunate to be supervised by Neil!

Today, the flagship paper of the UK Biobank Pharma Proteomics Project was published in nature.

nature.com/articles/s4158…

The results are fully browsable at ukb-ppp.gwas.eu.

The underlying protein measures will become available to UKB researchers in the next few weeks.