2ndCA/Dediff week 7/7
Do other treatments cause 2nd CA?
Danish study 910 patients lymphoma S/P high-dose chemotherapy and autologous HSCT
· 2nd CA rate higher than matched controls (HR 2·35).
· Cumulative risk 2nd CA at 10yrs 20%
thelancet.com/journals/lanha…

2ndCA/Dediff week 6/7
Do other treatments cause 2nd CA?
U Penn study CAR T:
· 449 patients median F/U 10 mos
· Projected 5-year cumulative incidence 2ndCA 15% for solid & 2% for hematological malig
rdcu.be/dGSMR

2nd CA/Dediff week 2/7
In tumor board/practice how many times have you seen 2nd tumor develop near prior tumor w/NO prior RT?
Cahan’s criteria Over-Estimates RT as cause of 2nd tumors

Brendon Stiles My friend Brendon Stiles, you are focusing on the mouse data but not RCTs...

In humans, SABR decreases progression, sometimes increases OS. Even the one negative trial (BR-002) had a HR <1.

BTW still some space in the table any positive surgical trials 😉