Science Translational Medicine
@sciencetm
The mission of Science Translational Medicine (AAAS) is to promote human health by communicating leading research and policy in biomedicine.
ID: 248897605
https://www.science.org/journal/stm 07-02-2011 23:22:31
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We would like to share our most recent work on Ca2+ and mitochondrial metabolism in CML "Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia" Published in Science Translational Medicine science.org/doi/10.1126/sc…
Applying 4D CT scanning, researchers probe how #MechanicalVentilation pressure impacts lung #biomechanics and lung strains in sheep, and calculate “break points” that could guide personalized and less injurious ventilation in the clinic. Columbia Anesthesiology scim.ag/83V
An improved #PETImaging agent for #Aspergillus infections displays strong specificity for the fungus in mice, and could address the lack of rapid and reliable diagnostic tools for these opportunistic pathogens. Dima Hammoud NIH Radiology and Imaging Sciences scim.ag/854
Why are poor respiratory outcomes so common after #LungResection? Researchers show the procedure triggers #eosinophil maturation, activation, and #inflammation that damages lung tissue in mice, which can be targeted with a NOS inhibitor. Department of Surgery, University of Maryland scim.ag/87M
Applying 4D CT scanning, researchers probe how #MechanicalVentilation pressure impacts lung #biomechanics and lung strains in sheep and calculate “break points” that could guide personalized and less injurious ventilation in the clinic. Columbia Anesthesiology scim.ag/88c
One quarter of the world’s population lives with #helminth infections. Now, research in mice shows helminths can disrupt #Tcell immunity from #SARSCoV2 vaccines, with implications for future vaccine design and deployment. msdiamondlab WUSM Department of Medicine scim.ag/88Z
Supplementation with the hunger-inducing peptide ACBP can treat #anorexia linked to stress or chemotherapy in mouse models, according to new research that could address a lack of therapies for this eating disorder. Centre de Recherche des Cordeliers scim.ag/89W
Excited to share our latest pancreatic cancer findings in collaboration with Prabhani Atukorale's group and led by former postdoc Loretah Chibaya and current research associate Kelly DeMarco in our lab. science.org/doi/10.1126/sc…
1/ Excited to share our latest paper published in Science Translational Medicine! 🧬 science.org/doi/10.1126/sc…. This journey was a true team effort with Yongjin Park, Liang, and Matt, under the guidance of David Hafler and Manolis Kellis. Here's a breakdown of our findings.
In a new analysis of mouse and human lung tissue, researchers show that loss of modification of the #mRNA Foxo1 can lead to impaired vessel splitting, also called #intussusception. Sichuan University scim.ag/8cm
Why are poor respiratory outcomes so common after #LungResection? Researchers show the procedure triggers #eosinophil maturation, activation, and #inflammation that damages lung tissue in mice, which can be targeted with a NOS inhibitor. Department of Surgery, University of Maryland scim.ag/8dc
Two recent phase 1 trials hint that bivalent #CARTcell therapies could overcome persistent barriers in the treatment of #glioblastoma, according to a new Focus. scim.ag/8e9 Joshua Bernstock E. Antonio Chiocca, MD, PhD, FAANS Brigham and Women's Neurosurgery
In a new study, researchers utilize #epigenomic and #transcriptomic profiling of people with relapsing-remitting #MultipleSclerosis to identify pathways involved in regulatory #Tcell dysfunction in autoimmunity. Tomokazu Sumida David Hafler scim.ag/8eO
Innate immune activators packaged in lipid nanoparticles, and paired with two senescence-inducing chemotherapy agents, controlled tumor growth and extended survival in a mouse model of pancreatic ductal adenocarcinoma. Science Translational Medicine scim.ag/8eZ
