Why do some fetuses exposed to #Zika virus develop congenital syndrome? Our study may have one answer- now out in Science Translational Medicine “Exacerbated Zika virus–induced neuropathology and microcephaly in fetuses of dengue-immune nonhuman primates” #ScienceResearch

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Parsing data from two clinical trials, researchers at Medical Biophysics discover that anti-commensal antibodies to three gut bacterial species associate with a better response to #Teplizumab , the first FDA-approved therapy that can delay #Type1Diabetes . scim.ag/4Bm

It’s #OAWeek and I’d like to take the opportunity to highlight how publication at Science Magazine, which supports Green Open Access, helped our genomics paper reach an especially wide audience at no cost to us. 😇
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A #translational study evaluating the role of #skin #microbiome in driving IL-1b #immunopathology in a parasitic infection, cutaneous #leishmaniasis .
Daniel Beiting Tej Pratap Singh Fernanda Novais Victoria Lovins Scott Lab Jordan Harris #eGrice science.org/doi/10.1126/sc…

Check out our viewpoint Science Translational Medicine in which we discuss the increasing threats posed by zoonotic mosquito-borne viruses. We emphasize the need for global preparedness through proactive measures of prediction, surveillance, prevention, and treatment.

science.org/doi/full/10.11…

Our work to provide high-quality journals that publish curated cutting-edge research across disciplines, as well as in-depth news and commentary, wouldn’t be possible without the dedicated support of global librarians who continue to subscribe to our journals—and our mission. 1/4

New experiments tie high burdens of Staphylococcus in the skin #microbiome to slower healing and stronger inflammatory responses in patients with cutaneous #leishmaniasis —and hint that targeting IL-1-beta might accelerate lesion healing.
Penn Vet scim.ag/4yc

In a new Review, researchers discuss the threats posed by “backyard #zoonosis ” from companion animals and peri-domestic species, accounting for the human-animal interface and population dynamics. Amandine Gamble Gary R. Whittaker Cornell Atkinson Center for Sustainability Cornell University College of Veterinary Medicine scim.ag/4xf

New experiments tie high burdens of Staphylococcus in the skin #microbiome to slower healing and stronger inflammatory responses in patients with cutaneous #leishmaniasis —and hint that targeting IL-1-beta might accelerate lesion healing. Penn Vet scim.ag/4wt

This week, Anthony Fauci argues that the world must heed the harsh lessons learned from the #COVID19 pandemic—for both scientific research and public health strategy—to prepare for the inevitable emergence of the next #pandemic pathogen. GU Medical Center scim.ag/4vZ

The new special issue on zoonotic diseases has arrived! Articles this week explore the latest research and counterstrategies for zoonotic threats, including an Editorial from Anthony Fauci and research on how the skin microbiome influences leishmaniasis.

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New research identifies 15-PGDH as a “gerozyme” linked to muscle wasting and #denervation during aging and after nerve trauma—and shows that 15-PGDH inhibitors halt muscle denervation in aged mice and rodents with nerve crush injuries. Stanford Immunology scim.ag/4uA

In 21 papers across Science, Science Advances, and Science Translational Medicine, the #BICCN consortium presents an atlas of the human and nonhuman primate brain in unprecedented detail.

The results uncover the genetic organization of the human brain. scim.ag/4u6 (THREAD 🧵)

Researchers at UCLA Chemical and Biomolecular Engineering formulate nanocapsules that boost antitumor #Tcell responses and can potentiate standard checkpoint blockade #immunotherapy in mice by delivering hydrogen peroxide and lactate oxidase to break down #lactate . scim.ag/4tv

Proud to share our hard work Camila Macedo Both Starzl Transplantation Institute published this week in Science Translational Medicine harnessing the potential of regulatory immunotherapy in an early clinical trial

An experimental #mRNA vaccine for #mpox shows promise in mice and induces strong neutralizing antibody responses—hinting it could fill the need for safer and more potent vaccines for mpox and future poxvirus outbreaks. Moderna scim.ag/4sF

A topical gel that inhibits MEK and suppresses the development of cutaneous squamous cell carcinoma ( #SCC ) could address the need for safe and tolerable chemopreventative agents for patients at risk of this common #SkinCancer . Kenneth Y. Tsai Stanford Medicine scim.ag/4sb

A team led by Lillian Tran finds that infusions of regulatory #DendriticCells from liver transplant donors can “teach” recipients’ T cells to tolerate grafts, and could potentially reduce patient reliance on standard immunosuppressive drugs. Starzl Transplantation Institute science.org/doi/10.1126/sc…