Can epilepsy surgery halt - or even reverse - cognitive decline in children? 🧠👶

To answer this, we studied long-term neuropsychological trajectories before and after epilepsy surgery.

Honoured to have this published in Brain
🔗 tinyurl.com/2s3wu9u6

🧵Main findings:

⭐Congratulations to the Danish Epilepsy Centre (Filadelfia Epilepsihospital), member of the ERN EpiCARE, for their great achievements in epilepsy care and research! An opportunity to thank the team for their contributions to our Network’s activities.
EU One Health HaDEA

In a retrospective study, Eriksson et al. show that epilepsy surgery was able to halt and even reverse a decline in neuropsychological functioning in certain children by providing seizure freedom and the opportunity to discontinue antiseizure medication. tinyurl.com/2s3wu9u6

Characterizing Frontal Lobe Seizure Semiology in Children - van Dalen - Annals of Neurology onlinelibrary.wiley.com/doi/abs/10.100…

Cerebral Cortical Surface Anatomy
Cortical Surface Signs

#radiologicalillustration ✍️
pixel by pixel handmade!

When do you suspect DCI in qEEG? These are the highlights. Created between EEG-texts with our cool and very talented Erafat Rehim

#NeuroTwitter #MedEd #EEG Emory & Grady Neurocritical Care Fellowship Casey Albin, MD Rebecca E. Matthews, MD Zeke Gleichgerrcht, MD, PhD EEGTalk

I am happy to share our most recent work on Channelopathies in Epilepsy. An amazing review led by Dr Andy Cheuk Him Ng... rdcu.be/dEClo

Welcome to the team Chiara Ferrazzoli, Chiara Bagliani and Emilia Ricci - we are delighted to have you on board 🤩

Looking forward to working with you on #GABRG2 , #KCNA2 , #IQSEC2 and #SCN8A 💪

#Epilepsy 🧠 #Genetics 🧬 #PrecisionMedicine 💊 #StrongerTogether 💜 #Epilepsy Awareness

Out now - We publish 5 cases with the very rare seizure semiology of #ictalkissing and how it primarily embodies a network expression rather than conforming to a conventional focal point of origin. Paper & videos👇

onlinelibrary.wiley.com/doi/10.1002/ep…
Epileptic Disorders

#temporallobeepilepsy

New lab's paper. NaV1.1/Scn1a phenotype: homozygous patient's gain-of-function variant causes life-threatening apneas and brainstem depolarization; responds to sodium channel blockers. pnas.org/doi/10.1073/pn…. With S.Cestele, E.Tolner, Andreas Brunklaus , A.van den Maagdenberg, et al.

Risk Factors and Outcomes for Cerebral Palsy With Hypoxic-Ischemic Brain Injury Patterns Without Documented Neonatal Encephalopathy: bit.ly/3T7rCnp

#NeuroTwitter #Neurology

📤New calls on the Collaborative Genetic webpage are published! epi-care.eu/collaborative-…

EU Health - #HealthUnion HaDEA #epilepsy

Of all antiseizure medications with meaningful data, the lowest prevalence of major congenital malformations after prenatal exposure was observed in offspring exposed to levetiracetam, oxcarbazepine, and lamotrigine, finds longitudinal cohort study. ja.ma/3Tph4A6

Such a pleasure to be in Kuopio 🇫🇮 to talk about the importance of genetic testing for individuals with epilepsy 💜

Thank you for the invitation Kuopio Epilepsy Symposium Reetta Kälviäinen 😊

#Epilepsy 🧠 #Genetics 🧬 #PrecisionMedicine 💊 #StrongerTogether 💜

that’s a hell of a paper... for paediatricians, neurologists and radiologists: reduce your imaging and make the best out of your clinical examination! pubmed.ncbi.nlm.nih.gov/34773160/ Great Ormond Street Neurosurgery

The redefining and reinventing of the epileptogenic zone - to be presented by Professor Chauvel , our thought leader who is always at the forefront of SEEG.

Link: cmrccf.webex.com/cmrccf/j.php?M…

Webinar number: 2430 813 2713
 
‼️Webinar password: epilepsy

A global update on cenobamate based on real-world experience in over 100 000 patients
doi.org/10.1111/epi.17… Open access

#epilepsy #ILAE #cenobamate #DRESS #Cenobamate #Titration ILAE @epilepsiajourn Wiley Neuro

Key point: This ITC shows #stiripentol is at least as effective as #fenfluramine in reducing seizures in DS. Both are superior to cannabidiol regimens.
doi.org/10.1002/epi4.1…

#epilepsy #ILAE #cannabidiol #Dravetsyndrome #metaanalysis ILAE @epilepsiaopen Wiley Neuro

Here a very detailed review on Epileptic Encephalopathies, a reference for pathological mechanisms and phenotypes: journals.physiology.org/doi/abs/10.115…
written with Renzo Guerrini (as coordinator), Valerio Conti, Simona Balestrini, Aristea Galanopoulou and Fabio Benfenati.

Here's a nice meta-analysis of what we know about super-refractory status epilepticus

✅ About 25% die and 25% do well with minimal or no disability

✅ Median duration of status is >1 month (36 days)

✅ The median number of ASMs used is 5; no particular agent seems to work…