Intensive statin therapy immediately after mild ischemic stroke or high-risk TIA reduces the risk for a poor functional outcome vs delaying 72 hours, the INSPIRES trial shows. ms.spr.ly/6019gcFs7

FDA approval for a new treatment approach - anti-inflammatory agent - for patients with ACS/CAD. lnkd.in/et5BZ7pK

Doc, can my LDL-C be *too low* after a heart attack?

Apparently, not.

- *achieved LDL-C < 20 mg/dl* with PCSK9i
- 5y therapy
- greatest benefit
- no more AEs

Remarkable!

ahajournals.org/doi/full/10.11…

👏 Prakriti Gaba Michelle O'Donoghue

The CETP inhibitor obicetrapib lead to a 63% reduction in LDL and 95% reduction in small dense LDL particles, AND a 50% reduction in Lp(a)! lnkd.in/e-9K7mNG

Congratulations! well deserved!

Many thanks to the many friends and colleagues who have reached out to me today. After 11 wonderful years Stanford Department of Medicine Stanford Medicine Stanford Health Care Rhonda and I look forward to heading back east for this incredible opportunity Weill Cornell Medicine Cornell University More in days ahead!

More pharmacologic validation ANGPTL3 target today by ArrowheadPharma

ANGPTL3 siRNA in homozygous familial hypercholesterolemia led to:
~80% lowering plasma ANGPTL3
~45% lower LDL-C!!

Pharmacology 2023 (L) as predicted by the human ANGPTL3 knock-outs identified in 2010 (R)

Clinicians can advocate for patients when PBMs change coverage rules. Here’s how: ow.ly/23iM50NRpqt
Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 Seth J. Baum MD

When one PBM removed a popular anticoagulant from their formulary, 20% of patients stopped treatment medicine altogether. Learn more: ow.ly/LYWg50NRpcO
Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 Seth J. Baum MD

Congrats Family Heart Foundation on new study

of homozygous FH patients in CASCADE FH U.S. registry, and identification of patients in large eHR database

highlighting exciting opportunities to inc diagnosis and close treatment gaps for this high-risk condition

ahajournals.org/doi/10.1161/JA…

Updated guideline on Homozygous FH. lnkd.in/eEFaJ8Rr

Family Heart Foundation [b] While this is ongoing, being able to come together and raise awareness of Lp(a) to ensure there is education around #KnowLpa to inform the public of this underdiagnosed but common condition is crucial and something that will help transform outcomes for those living with Lp(a)

It was great to have participated on #KnowLpa tweetathon, we must reach lots o people to reduce #CVD thanks Family Heart Foundation

Thank you everyone for your efforts this #LpaAwarenessDay ! Let's raise our voices by sharing on social media or simply having a conversation. Together, we can save #morefamiliesmorehearts . #KnowLpa #FINDLpa

I hope today helps more people #KnowLpa . There is an urgency here. In honor of my sister Catherine I will continue to shout about #LpaAwareness from the mountain tops! Thanks for the platform #FamilyHeartFoundation

This #LpaAwarenessDay we are asking you to consider giving $20 in honor of the 20% who have high Lipoprotein(a). To continue our work, each year we must raise funds from the community we serve. The more donors who give and the more dollars we raise, the more we can do. #KnowLpa

#KnowLpa #LowerYourRisk

Over 60 million Americans are living at high risk for aggressive cardiovascular disease and don't know it.... #KnowLpa

If you are wondering why you don't #KnowLpa yet, this is a key reason. #GetTested #KnowYourRisk #KnowledgeisPower

#KnowLpa