Now on bioRxiv - Temperature Sensitive Glutamate Gating of AMPA-subtype iGluRs 🧠🔥❄️🔬 In this preprint, we reveal how glutamate gating of iGluRs is unique from PAM-activated states (!!!), and how temperature effects glutamate gating. biorxiv.org/content/10.110…

Cryo-EM structure of the R388 plasmid conjugative pilus reveals a helical polymer characterized by an unusual pilin/phospholipid binary complex dlvr.it/TD1XsT

New from the Bartesaghi lab: MiLoPYP is a two-step, dataset-specific contrastive learning-based method for fast and accurate detection and localization of a diverse range of target structures in cryoET, enabling improved in situ structural biology. nature.com/articles/s4159…

Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1 dlvr.it/TD1rx9

Structure of the iminium reaction intermediate in an engineered aldolase explains the carboligation activity toward arylated ketones and aldehydes dlvr.it/TD24Z1

Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity dlvr.it/TD2N8M

They all rock: A systematic comparison of conformational movements in LeuT-fold transporters dlvr.it/TD3TTb

Crystal structure of lipase from Pseudomonas aeruginosa reveals an unusual catalytic triad conformation dlvr.it/TD3t0J

Structural insights into an atypical histone binding mechanism by a PHD finger dlvr.it/TD4Bml

Cryo-EM structures reveal the molecular mechanism of HflX-mediated erythromycin resistance in mycobacteria dlvr.it/TD4Q86

Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling dlvr.it/TD4j8V

Structural review of SARS-CoV-2 antiviral targets dlvr.it/TD5rXd

Just released in #EMDB and published in Structure: 3.5 Å #Cryo-EM structure of #Calcineurin bound to #PI4KA, revealing a dual interface in both PI4KA and #FAM126A!

Antiterminator LoaP loads onto RNA to chase a runaway RNA polymerase dlvr.it/TD6F2T

Ping, pong, and freeze: Structural insights into the inhibition of ceramide synthase by Fumonisin B1 dlvr.it/TD6YJR

Expanding the insect defensin landscape dlvr.it/TD6mmF

Ordering the disordered dlvr.it/TD73fT

RNA dynamics from experimental and computational approaches dlvr.it/TD89Xm

Online now! Structural organization of pyruvate: ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina acetivorans dlvr.it/TD8YzM

Online now! Rewiring protein binding specificity in paralogous DRG/DFRP complexes dlvr.it/TDBryt