After 𝘻𝘦𝘵𝘢, here comes 𝘦𝘱𝘴𝘪𝘭𝘰𝘯 🥳:
We present CD3ε gene editing as a GMP-compatible strategy uniquely suited to create potent Tregs with redirected antigen specificity for adoptive cell therapy.
#Treg #CARTreg #EUhorizon2020 #ReSHAPE
biorxiv.org/content/10.110…

New preprint alert! 🚨🚨

Droplet-based single-cell profiling of somatic epimutations enable high-res natural lineage tracing.

A super fun collaboration with Centre for Genomic Regulation (CRG), co-supervised with Lars Velten, and co-led by Michael Scherer and Indranil Singh!

biorxiv.org/content/10.110…

🔥 story lead by Michael Scherer & Indranil Singh, with Alejo Rodriguez-Fraticelli, PhD: epimutations stably mark clones in hematopoiesis over months and years, and can be read out at scale using targeted single-cell, single-CpG-resolution profiling of DNA methylation🧵biorxiv.org/content/10.110…

📢 How can we identify cell lineages from any scRNA-seq dataset ? Check our paper: nature.com/articles/s4146…. Very proud of massive amount of beautiful work by Almut Eisele, A. Dormann + fantastic collaboration with Marcel Tarbier and Pelechano lab. A 🧵

Identifying immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors biorxiv.org/content/10.110…

What a PERFFect day to share our new preprint!

With Tsion Abay #BobStickels Meril Takizawa Ronan Chaligne (He/Him) and Ansu Satpathy, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.110… 1/n

Excited to share a piece that we wrote on clonal NK cell responses. Especially the last chapter was fun to write as it gave us the opportunity to tap a bit into literature on clonal selection and adaptation from different contexts. Romagnani Lab doi.org/10.1111/imr.13…

Best way to start a week: Our story on CD3-zeta gene editing to create CAR-T and CAR-NK cells is online at Blood Journal 🩸 🧬 🙌

Thanks to the entire team led by Jonas Kath and all collaborators! 🙏

ashpublications.org/blood/article/…

What would happen if you got vaccinated against the same antigen over and over again? In The Lancet Infectious Diseases, we now report on a hypervaccinated individual from Magdeburg (HIM) who received 217 vaccinations within 29 months against SARS-CoV-2. 👇 1/19 thelancet.com/journals/lanin…

1/ Just in! We report the first humans with inherited pre-TCR⍺ deficiency in @sciencemagazine. Dive into our fascinating findings on complete and partial forms of pre-TCRα deficiencies, including a common variant in the Middle East and South Asia. science.org/doi/10.1126/sc…

Excited to share our latest work led Elia Moreno Cubero, PhD Aljawharah on NK cell mitochondrial dysfunction in HIV-1 infection #HIVcure IIT Ane Ogbe Uppy Gill Rowland-Jones Lab SchurichLab Michael Dustin Ian Charleson Day Centre Mortimer Market Centre, Tottenham Court Road
insight.jci.org/articles/view/…

Dear fellow lab rats: which tools do you use for designing multiplex PCR primers for targeted amplification of human genomic DNA regions?

Happy to see this out Immunity: cNK cells establish tissue residency upon acute skin infection. Tcf7+CD69+ trNK resemble CD56bright NK cells in human tissues, and mediate rapid secondary responses. Thanks to the fantastic WüSI - Systems Immunology Würzburg team + all collabs! cell.com/immunity/fullt…

Looking forward to our next #globalimmuno talk this Wednesday, November 8st at 9am PST, noon EST, 4pm GMT by Dr. Chiara Romagnani.

Title: “Adaptive features of Natural Killer cells”
LINK: ucsd.zoom.us/j/91053505061

1/n By applying probabilistic models implemented in scVI-tools, we created a transcriptional reference map of human blood and tissue resident NK (TrNK) cells from normal tissues including blood, pancreas, lung, breast, skin, prostate and brain. biorxiv.org/content/10.110…

We wrote a lil something about immune memory in ILCs. Hope it’s informative. There are still so much to discover! Joseph Sun Lab
nature.com/articles/s4159…

Induction of an hypoimmune state through unidirectional manipulation of the immune synapse. Work by outstanding Quirin Hammer and Karlo Perica in a fun collaboration with @Michel_Sadelain, ÖnfeltLab and Fate Therapeutics. biorxiv.org/content/10.110…

Prof. Dr. Chiara Romagnani ist jetzt Professorin für Medizinische #Immunologie an der #CharitéBerlin und hat die Leitung des Instituts für Medizinische Immunologie übernommen. Wir gratulieren Romagnani Lab!
charite.de/service/presse…

Delighted that our paper 'Innate receptors with high specificity for HLA class I–peptide complexes' is now published in Science Immunology Science Immunology

science.org/doi/10.1126/sc….

I am really honored to receive this award and would like to express my gratitude to everyone involved for their continuous support. Romagnani Lab LeifLudwig Caleb Lareau Mashreghi_Lab DRFZ