Are you gonna help to accelerate?

IL-11 antagonists, trametinib and now Salvia haenkei extract. It is a good year for mouse lifespan studies that meet our 900-day rule, don't you think? Diogo Barardo, PhD. & Time Breaker Matt Kaeberlein

Rapamycin PEARL Study Results: We detected dose-dependent (10 mg group) and sex-specific improvements in lean tissue mass, pain, social functioning, overall QoL, and overall osteoarthritis score in females, and in bone mineral content in men. medrxiv.org/content/10.110…

Been saying for a while cancer is not as easily modifiable as is CVD. Avoiding CVD is almost trivial now. What we need are cancer breakthroughs. It is of note here that many anti-aging drugs are strongly protective from cancer e.g. rapamycin, trametinib and Nrf2 activators.

We need longevity research NOW. The fertility crisis is approaching fast.

MSCs and apheresis in alzheimer's disease are low key promising. Parabiosis keeps on giving. neurologylive.com/view/fda-grant…

Gm who is coming to token 2049? ✋ Let's cross path at the DeSci Summit! Join us on Sept 16th at National Gallery Singapore for the DeSci & bio/acc Summit during TOKEN2049! lu.ma/descisummit

Have you read this article about Cerebrolysin ?Bryan Johnson /dd lesswrong.com/posts/ZznBxPdZ…

e/acc and bio/acc >> doomers Let's forge a bright future using all the available tools instead of fear! Join us on the 16th for a Singapore-based event to discuss decentralized science and biology, supported by VitaDAO 💛 Max Unfried and many others. meetup.com/singapore-long…

Impressions from #ARDD2024, what we learned and how we can make it even better. geroscience.substack.com/p/impressions-… It was a great ARDD Meeting with Max Unfried Brian Kennedy and VitaDAO 💛

We need to use pre-registration more often. In fact, there should be a journal that publishes study protocols or a database. One can even allow a minor delay in publishing the pre-reg to encourage authors...

It is a bad argument to say that occupational physical activity is "below the physiological threshold for improvement or maintenance of CV health" and yet at the same time measure step counts and claim that walking promotes health. One or the other please. ncbi.nlm.nih.gov/pmc/articles/P…

Do you have data on bioavailability of your rapamycin formulation Healthspan? Curious to know given the results from PEARL using compounded rapa.

Total cancer survival rates are a misleading statistic in the "war on cancer" and "war on aging" due to stage shift. If one is interested in *therapeutic* improvements the statistic to look at is stage III and IV survival.

Likely that ethicists are gonna stall science again and thereby preventing cures for diseases and aging.

It is amazing that ERK emerges as the one thing that connects two of the most important mouse lifespan papers of 2024. (Linda Partridge, Stuart Cook)

Highlighting some cool work by Ora Biomedical, Inc. Matt Kaeberlein Donate/sponsor your own compound of choice to be tested in worms, what could be more fun? They even got a cool leaderboard! orabiomedical.com/mmcleaderboard/

With all due respect, if you say yourself that menopausal hormonal changes are harmful than they are per definition a defect. Just because aging is horrible does not mean that older people are worth less than young people. BUT aging *is* HORRIBLE. youtube.com/watch?v=exQcs5…