Our method for stratifying patients with acute infections (sepsis, COVID-19 and flu) from transcriptomic data is now out. A great collaboration with Knight Genetics led by Eddie Garcia science.org/doi/10.1126/sc…

A huge fan of this work--especially neat to see that, although rare variants contribute much less to missing heritability and risk stratification (expected), they mechanistically converge with common variants (which is non-intuitive but has powerful implications)

Excited to share our work on genome editing for SMA in Science Magazine! We evaluated dozens of strategies targeting SMN2 regulatory sequences to rescue SMN levels, and show that one-time in vivo co-administration of our top strategy with nusinersen extends lifespan of SMA mice.

So excited to share our #RheumatoidArthritis tissue chromatin atlas of 87K cells from 30 individuals! With, Soumya Raychaudhuri সৌম্য রায়চৌধুরী, Saori Sakaue, Aparna Nathan, Laura Donlin, Kevin Wei and #AMP-RA! NIAMS. biorxiv.org/content/10.110… (Tweeting on behalf of the talented Kathryn Weinand)

Lucky to have had such incredible mentorship 😊

Out today nature – our analysis of the influences of common nuclear DNA variation on mitochondrial DNA copy number and heteroplasmy across >250,000 people across two biobanks! disq.us/t/4ibyjjo

🆕 New in nature! Dr. Raychaudhuri (Soumya Raychaudhuri সৌম্য রায়চৌধুরী) and collaborators including Jen Anolik, Laura Donlin, and Deepak Rao constructed a comprehensive RA #synovial tissue reference that revealed diverse cellular composition. Brigham and Women's Hospital 📖 Full story: bit.ly/46a8V70

Can we precisely rewrite the genetic code - make a single DNA spelling change - in the liver of a human being for clinical effect? YES! Scientific milestone: VERVE-101 provides first proof-of-concept for in vivo DNA base editing in humans Clinical implication: It’s early

Exciting day for the lab! Two papers out in Nature Genetics, both about integrating genetic data with single cell data! Special thanks to lead authors Anika Gupta and Joyce Kang, PhD rdcu.be/dsrz2 rdcu.be/dsrzB

Excited that our single-cell eQTL study of HLA genes is out now in Nature Genetics! ⭐️ nature.com/articles/s4158… Huge thx to Soumya Raychaudhuri সৌম্য রায়চৌধুরী Saori Sakaue Yang Luo for their guidance Check out this great News & Views by the Gaffney lab describing the key points: nature.com/articles/s4158…

An inspiring gathering of our social science MD-PhD students & faculty to share their research initiatives at the intersection of medicine & health policy, economics, epidemiology, history, anthro, sociology, & more. Amazing company & talks! NIGMS Training & Capacity Building The National Institute on Aging (NIA) Harvard Medical School