Excited to share a new preprint from Tom Cupedo lab where we used #scRNAseq and functional studies to investigate the composition and function of the bone marrow #NKcell compartment in #myeloma at diagnosis, during treatment, and at relapse.

biorxiv.org/content/10.110…

Nature research paper: Evolution of a minimal cell go.nature.com/46D4GSO

Honored to write this commentary with my amazing mentor, Dr. Anderson, on determinants of response & resistance to bispecific t-cell engagers in #MultipleMyeloma #mmsm . So much to learn about the complexity of the immune system and optimizing TCEs! Dana-Farber Dana-FarberNews

This week in Nature: Human pangenome – data from 47 individuals combine to create reference resource that reflects human diversity. Browse the full issue: nature.com/nature/volumes…

How my training helps me to address health disparities in multiple myeloma go.nature.com/3HZTaGE

‼️ The PANGEA Model is out now The Lancet Haematology ‼️

A 🧵on how PANGEA improves prediction accuracy of MGUS & SMM progression to #MultipleMyeloma & is the 1st model that is #personalized to the individual #mmsm patient! Ghobrial Lab Dana-Farber | 1/

sciencedirect.com/science/articl…

From the February issue—
Genomic profiling of circulating #multiplemyeloma cells, by Ankit Dutta, JB Alberge, Gaddy Getz, . et al.
bit.ly/3Ih5NMN
Gad Getz Laboratory Ghobrial Lab Dana-Farber Broad Institute #LiquidBiopsy #CirculatingTumorCells

The Gadrial retreat (Getz+Ghobrial labs) was a great success ⁦Gaddy Getz⁩ ⁦Gad Getz Laboratory⁩ ⁦Ghobrial Lab⁩ ⁦Promise Study⁩ #mmsm . Great ideas to tackle scientific challenges. Thank you all for the amazing work you do.

Nice Cancer Discovery #MMsm paper by . lab! # CTCs clearly increased from MGUS to SMM marching up 20/2/20. More importantly, genetic profiling of 🩸 CTCs identified all BMBx FISH findings + more.

Given 🐠 not always done / not as sensitive, possible game changer some day!

MinimuMM-seq: Genome Sequencing of #CirculatingTumorCells for Minimally Invasive Molecular Characterization of #MultipleMyeloma Pathology, by Ankit Dutta, JB Alberge, Gaddy Getz, Gad Getz Laboratory, . et al.
bit.ly/3Ikzr5v
Ghobrial Lab Dana-Farber Broad Institute

A new technique developed by Dana-Farber researchers offers a promising ability to detect and analyze multiple myeloma tumor cells using a simple blood sample. dana-farber.org/newsroom/news-…

MinimuMM-seq: Genome Sequencing of #CirculatingTumorCells for Minimally Invasive Molecular Characterization of #MultipleMyeloma Pathology, by Ankit Dutta, JB Alberge, Gaddy Getz, Gad Getz Laboratory, . et al.
bit.ly/3FLN8c1
Ghobrial Lab Dana-Farber Broad Institute

Looked at today’s #ASH22 posters before leaving - if you stop by #4457 presented by Ankit Dutta check out the recent Cancer Discovery paper on this work in #MultipleMyeloma aacrjournals.org/cancerdiscover…

Presenting tonight our work on MinimuMM-seq #ASH22 Poster 4457! Come by to discuss detection and genomic profiling of circulating tumour cells for key myeloma biomarkers! JB Alberge . Ghobrial Lab Gad Getz Laboratory #mmsm

Congrats to ⁦Ankit Dutta⁩ on his #ASH22 Abstract Achievement Award on MinimuMM-Seq work #mmsm ⁦.⁩ ⁦Ghobrial Lab⁩ ⁦Gaddy Getz⁩ #mmsm

Beautiful work by Liz Lightbody at #ASH22 showing the power and promises of CTC #scRNAseq in #myeloma and discovering new features and biology of MM #CTCs in the process ⁦Ghobrial Lab⁩ ⁦.⁩ #mmsm

Single cell sequencing of circulating tumor cells ⁦Ghobrial Lab⁩ ⁦Gad Getz Laboratory⁩ ⁦Dana-Farber⁩ #ash22 ⁦Bruno Paiva⁩. CTCs in predicting progression but not just the numbers

📣First of many CTC abstracts at #ASH22 #mmsm
Super study by . Ghobrial Lab with thousands of single CTCs being sequenced. Consistent results with Spanish data Juanjo Garcés

I continue believing that these data will deliver pathways to prevent disease dissemination!

Excellent presentation on molecular profiling of circulating tumour cells in precursor multiple myeloma from Dr. Elizabeth Lightbody! Towards an improved understanding of CTC biology/extravasation, and clinical utility of liquid biopsies for patients! Ghobrial Lab #mmsm #ASH22

First of a number of presentations at #ASH22 by ⁦Ghobrial Lab⁩ on this amazing #scRNAseq cohort of progression from MGUS->MM, the largest to date. Nicely done by Junko #mmsm ⁦.⁩ ⁦Gaddy Getz⁩