Always be selling. Also TIL fred_luddy started ServiceNow at age 50!

"A great man is hard on himself; a small man is hard on others." — Confucius

Few policies are as ruinously destructive to society as those that reduce growth.

Who wants to live in this world?

Machine learning pioneer Andrew Ng says AGI is still "many decades away, maybe even longer" and companies that say it is only a year or two away are using non-standard definitions to lower the bar

The common theme from Brian Chesky’s observations on running Airbnb to Elon Musk on “hardcore mode” is to question the role of professional managers. It’s a bit of a reckoning of the PMC across tech.

Another ctDNA test that fails to yield as good sensitivity & specificity as medical imaging (in this case, a colonoscopy).

Every so often I’ll read a PG essay and feel as if he peeked into my brain and wrote something I was thinking but couldn’t quite articulate. This is one of those essays 👇👏🫡

VC Mode: by the pool in the Hamptons texting founders about Founder Mode

it’s called “founder mode” it’s about how to run your company as a founder and how that often goes against traditional management practices. it’s basically what i already do but paul graham created a cool name for it in his latest essay. you know who paul graham is? y combinator?

What founder mode looks like for me.

We should use soft-max to mean "log of sum of exponentials." What is often called soft-max should really be called soft-argmax. Even John Bridle, who coined the word soft-max, agrees.

We booked more scans at Ezra® in August than we did in June & July... combined. Am I doing founder mode right?

steve jobs embodied founder mode before it was a thing. but few understand that he deployed manager mode in the right way when it came down to it. this is my favorite interview of his where he's talking about his management principles 👇

new favorite example of the regulatory state: preschool is not allowed to remove bee stingers from kids. using tweezers is considered surgery.

Will be speaking at Bryan Johnson /dd's Don't Die Summit in San Francisco this Sunday. There's still time to sign up: dontdiesummit.com/san-francisco#…

This (fortunately) doesn't happen often, but yesterday an Ezra® scan detected a bleeding arteriovenous malformation (AVM) in a member's brain. She was asymptomatic and had no idea she had a brain hemorrhage. We sent her to the ER and likely saved her life.

Another banger essay from my buddy Packy 👇🔥