Phage 2, E. coli 2. PARIS, A defense system that detects phage encoded suppressors of defense, triggers abortive infection. Out of left field, a phage that evades abortive infection by bringing its own tRNA. Phage 3, defense 2…what’s next? Such a cool project to be a part of!

H-NS is a bacterial transposon capture protein !!! biorxiv.org/content/10.110…

💥Our new preprint! Transposon ADDICTION in development! Gag proteins of endogenous retroviruses are required for zebrafish development Study led heroically by Sylvia Ni & Jonathan Wells This work has transformed my view of transposons, no less! 🧵1/n biorxiv.org/content/10.110…

That amazing paper you spent years on? That amazing breakthrough you had? Very likely you built this following the work of others (very few exceptions), just as others will build off yours. Science is a continuum. Want to leave a lasting legacy in science? Be generous & be kind.

Cellular repair of DNA breaks enables editing of the human genome. Do human cells repair RNA breaks, and can we use it to edit transcriptomes? Our work with Anna Nemudraia and Wiedenheft Lab is now online in Science Magazine! #ScienceResearch science.org/doi/10.1126/sc…

We show that CRISPR-guided RNA breaks are repaired in human transcripts, and we leverage this process to make programmable RNA excisions that restore gene function.

Nemudryi lab will open in September of 2024 at UF Medicine! We will use programmable ribonucleases to study how human cells repair RNA and how RNA viruses co-opt these mechanisms for their benefit. Interested? Get in touch! nemudryi-lab.com

New article from Will Henriques Janet Young (she/her) 🍎 🌈 Artem Nemudryi, PhD Anna Nemudraia Wiedenheft Lab Harmit S. Malik: The Diverse Evolutionary Histories of Domesticated Metaviral Capsid Genes in Mammals buff.ly/3U5QZX7 #science #evolution #biology #genome

Montana State scientists’ research on RNA editing illuminates possible lifesaving treatments for genetic diseases montana.edu/news/23722/mon…

Ancient viral genes repurposed for functions in mammalian reproduction. 🤯 Super excited to see this up on bioRxiv. Very grateful to be a part of this collaboration!

I am delighted to share the latest preprint from our lab, which was work that was conceived and led by Jeannette Tenthorey during her postdoc and during the first few months of her independent lab at UCSF. biorxiv.org/content/10.110… TL;DR: Indels matter. A lot. 1/

New activity on the Chan Zuckerberg Imaging Institute’s CryoET Data Portal bit.ly/3T9sZ6D ; segmentations can now be visualized in the browser for 15,000+ tomograms. We would love feedback bit.ly/3VUcHjc on how we can improve and expand.

Nature research paper: TnpB homologues exapted from transposons are RNA-guided transcription factors go.nature.com/4eETtFu

Crafted with ❤️ for the scientific community and totally open-source! Don't hesitate to get in contact.

Out today in nature! I am thrilled to share our work on the PARIS immune system in its final published form. Huge thanks to my mentor, Kevin Corbett Kevin Corbett, and my teammates. See the thread below in comment section for a quick summary! nature.com/articles/s4158…

nature Kevin Corbett Also, check out this parallel publication by Burman et al., who identified how phages can escape PARIS immunity and discovered the tRNA targeted by the PARIS system. Congrats!!! nature.com/articles/s4158…

Our story on RNA-templated gene synthesis in antiviral immunity is out today in Science Magazine! We discovered a cryptic gene, neo, that is created de novo by infected cells in a remarkable feat of molecular gymnastics🤸 science.org/doi/10.1126/sc…

I’m excited to share my 1st postdoc paper! The thread below summarizes the main findings of our study. biorxiv.org/content/10.110…

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/